Injectable glucose oxidase-immobilized gelatin hydrogel prevents tumor recurrence via oxidation therapy

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2023-10-06 DOI:10.1016/j.colsurfb.2023.113581

Changkyu Lee

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引用次数: 0

Abstract

In clinical practice, surgery is the preferred treatment for breast cancer; however, the high recurrence rate due to residual tumors after surgery remains a major issue. Hydrogels can reduce the side effects of residual tumors and exert strong anticancer effects, thereby showing potential as therapeutic agents for suppressing tumor recurrence after surgery. Glucose oxidase (GOD)-immobilized gelatin hydrogels (GOD-gelatin hydrogel) were prepared by bioorthogonal click chemistry. Then, the anticancer effect, tumor recurrence inhibition, and biodegradability of the resulting hydrogels were evaluated through cell and animal experiments. GOD-gelatin hydrogel showed cytotoxicity and anticancer effect via H₂O₂ generation. Unlike free GOD, GOD-gelatin hydrogel remained in the surgical site after implant and continued to suppress tumor recurrence over time. The proposed GOD-gelatin hydrogel system can be easily implanted at the surgical site after tumor surgery, representing a novel treatment to suppress tumor recurrence without any systemic toxicity.

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可注射葡萄糖氧化酶固定明胶水凝胶通过氧化疗法预防肿瘤复发。

在临床实践中，外科手术是治疗癌症的首选方法；然而，由于术后残留肿瘤导致的高复发率仍然是一个主要问题。水凝胶可以减少残留肿瘤的副作用，发挥强大的抗癌作用，从而显示出作为抑制肿瘤术后复发的治疗剂的潜力。采用生物正交点击化学法制备了葡萄糖氧化酶（GOD）固定化明胶水凝胶。然后，通过细胞和动物实验评估所得水凝胶的抗癌效果、肿瘤复发抑制和生物降解性。GOD明胶水凝胶通过产生H2O2表现出细胞毒性和抗癌作用。与游离GOD不同，GOD明胶水凝胶在植入后仍留在手术部位，并随着时间的推移继续抑制肿瘤复发。所提出的GOD明胶水凝胶系统可以很容易地在肿瘤手术后植入手术部位，代表了一种抑制肿瘤复发而没有任何全身毒性的新疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.