Regulatory mechanism of circular RNAs in neurodegenerative diseases

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2023-10-21 DOI:10.1111/cns.14499

Feng Xiao, Zhi He, Siqi Wang, Jiamei Li, Xiaolan Fan, Taiming Yan, Mingyao Yang, Deying Yang

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引用次数: 0

Abstract

Background

Neurodegenerative disease is a collective term for a category of diseases that are caused by neuronal dysfunction, such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Circular RNAs (circRNAs) are a class of non-coding RNAs without the 3′ cap and 5′ poly(A) and are linked by covalent bonds. CircRNAs are highly expressed in brain neurons and can regulate the pathological process of neurodegenerative diseases by affecting the levels of various deposition proteins.

Aims

This review is aiming to suggest that the majority of circRNAs influence neurodegenerative pathologies mainly by affecting the abnormal deposition of proteins in neurodegenerative diseases.

Methods

We systematically summarized the pathological features of neurodegenerative diseases and the regulatory mechanisms of circRNAs in various types of neurodegenerative diseases.

Results

Neurodegenerative disease main features include intercellular ubiquitin–proteasome system abnormalities, changes in cytoskeletal proteins, and the continuous deposition of insoluble protein fragments and inclusion bodies in the cytoplasm or nucleus, resulting in impairment of the normal physiological processes of the neuronal system. CircRNAs have multiple mechanisms, such as acting as microRNA sponges, binding to proteins, and regulating transcription. CircRNAs, which are highly stable molecules, are expected to be potential biomarkers for the pathological detection of neurodegenerative diseases such as AD and PD.

Conclusions

In this review, we describe the regulatory roles and mechanisms of circRNAs in neurodegenerative diseases and aim to employ circRNAs as biomarkers for the diagnosis and treatment of neurodegenerative diseases.

Abstract Image

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环状RNA在神经退行性疾病中的调节机制。

背景：神经退行性疾病是由神经元功能障碍引起的一类疾病的统称，如阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化症（ALS）。环状RNA（circRNA）是一类没有3'帽和5'聚（a）的非编码RNA，通过共价键连接。CircRNA在大脑神经元中高度表达，可以通过影响各种沉积蛋白的水平来调节神经退行性疾病的病理过程。目的：这篇综述旨在表明，大多数circRNA主要通过影响神经退行性疾病中蛋白质的异常沉积来影响神经退行病变。方法：系统总结了神经退行性疾病的病理特征以及circRNAs在各类神经退行性病变中的调控机制。结果：神经退行性疾病的主要特征包括细胞间泛素-蛋白酶体系统异常，细胞骨架蛋白变化，不溶性蛋白片段和包涵体在细胞质或细胞核中持续沉积，导致神经元系统正常生理过程受损。CircRNA具有多种机制，如充当微小RNA海绵、与蛋白质结合和调节转录。CircRNA是一种高度稳定的分子，有望成为AD和PD等神经退行性疾病病理检测的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.