“Afterglow” Photodynamic Therapy Based on Carbon Dots Embedded Silica Nanoparticles for Nondestructive Teeth Whitening

IF 15.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
ACS Nano Pub Date : 2023-10-20 DOI:10.1021/acsnano.3c05116
Hao Liu, Yikai Chen, Luoqi Mo, Fangdong Long, Yixiao Wang, Zhouyi Guo, Haolin Chen*, Chaofan Hu* and Zhiming Liu*, 
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Abstract

Teeth staining is a common dental health challenge in many parts of the world. Traditional teeth whitening techniques often lead to enamel damage and soft tissue toxicity due to the use of bioincompatible whitening reagents and continuous strong light irradiation. Herein, an “afterglow” photodynamic therapy (aPDT) for teeth whitening is proposed, which is realized by energy transition pathways of intersystem crossing. The covalent and hydrogen bonds formed by carbon dots embedded in silica nanoparticles (CDs@SiO2) facilitate the passage of energy through intersystem crossing (ISC), thereby extending the half-life of reactive oxygen species (ROS). The degradation efficiency of aPDT on dyes was higher than 95% in all cases. It can thoroughly whiten teeth by eliminating stains deep in the enamel without damaging the enamel structure and causing any tissue toxicity. This study illustrates the superiority of aPDT for dental whitening and the approach to exploring carbon-dots-based nanostructures in the treatment of oral diseases.

Abstract Image

基于碳点嵌入二氧化硅纳米颗粒的“余辉”光动力疗法,用于无损牙齿美白。
在世界许多地方,牙齿染色是一项常见的牙齿健康挑战。传统的牙齿美白技术由于使用生物不相容的美白试剂和持续的强光照射,经常导致牙釉质损伤和软组织毒性。本文提出了一种用于牙齿美白的“余辉”光动力疗法(aPDT),该疗法通过系统间交叉的能量转换途径实现。二氧化硅纳米颗粒中碳点形成的共价键和氢键(CDs@SiO2)促进能量通过系统间交叉(ISC),从而延长活性氧(ROS)的半衰期。aPDT对染料的降解效率在所有情况下都高于95%。它可以彻底美白牙齿,消除牙釉质深处的污渍,而不会破坏牙釉质结构和引起任何组织毒性。本研究阐明了aPDT在牙齿美白方面的优越性,以及探索碳点基纳米结构在治疗口腔疾病中的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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