{"title":"Engineering bone marrow-on-a-chip","authors":"Y. Torisawa","doi":"10.21037/MPS.2019.02.01","DOIUrl":null,"url":null,"abstract":"Bone marrow is the permanent hematopoietic organ; the main function is to produce blood cells for the body through life. The microenvironment of bone marrow contains a complex set of cellular, chemical, and physical signals to maintain the hematopoietic system (1-3). The hematopoietic niche regulates hematopoietic stem cells (HSCs) to facilitate a balance between self-renewal and differentiation into progenitor cells that produce all types of blood cells.","PeriodicalId":87327,"journal":{"name":"Microphysiological systems","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/MPS.2019.02.01","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microphysiological systems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/MPS.2019.02.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Bone marrow is the permanent hematopoietic organ; the main function is to produce blood cells for the body through life. The microenvironment of bone marrow contains a complex set of cellular, chemical, and physical signals to maintain the hematopoietic system (1-3). The hematopoietic niche regulates hematopoietic stem cells (HSCs) to facilitate a balance between self-renewal and differentiation into progenitor cells that produce all types of blood cells.