Effectiveness of ZiYin Xiehuo granules and Zishen Qinggan granules on partial precocious puberty in girls: a multicenter, randomized, single-blind, controlled trial
Sun Wen , Han Xinghui , Wang Yonghong , Yu Jian , Yan Weili , Zhao Jun , Chen Weibin , Xue Zheng
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引用次数: 1
Abstract
OBJECTIVE
To evaluate the effect of ZiYin Xiehuo granules (ZYXH) and Zishen Qinggan granules (ZSQG) on partial precocious puberty (PPP).
METHODS
This was a multicenter, randomized, single-blind, positive-controlled trial. A total of 143 patients were assigned to either the ZYXH group or the ZSQG group using a random number table. The ZYXH group received ZYXH three times daily for 6 months and the ZSQG group received ZSQG three times daily for 6 months. Mammary nucleus diameter; the results of uterus, ovarian, and maximum follicle measures; and Chinese medicine symptom pattern scores were compared at baseline and after 3 months and 6 months of treatment.
RESULTS
After 3 months’ treatment, there were no significant differences between the two groups in mammary nucleus index changes (left 3.4 ± 3.1 vs 3.5 ± 3.1, P = 0.790; right 3.0 ± 2.9 vs 3.6 ± 3.0, P = 0.719). The uterine volume in the ZYXH group was smaller than that in the ZSQG group (2.1 ± 1.6 vs 2.6 ± 2.2, P = 0.006). There were no significant between-group differences in ovarian volume and maximum follicular diameter on either side (ovarian volume: left 1.2 ± 0.7 vs 1.3 ± 0.6, P = 0.8; right 1.2 ± 0.7 vs 1.4 ± 1.1, P = 0.984; maximum follicular diameter: left 3.9 ± 1.7 vs 3.5 ± 2.2, P = 0.158; right 3.5 ± 1.7 vs 3.9 ± 2.1, P = 0.314).
CONCLUSION
ZYXH granules and ZSQG granules both affected the size of the mammary nucleus in girls with PPP, and improved Chinese medicine symptom patterns. ZYXH granules showed slight advantages over ZSQG granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles.
目的评价紫饮泻活颗粒(ZYXH)与紫肾清肝颗粒(ZSQG)治疗部分性性早熟(PPP)的疗效。方法多中心、随机、单盲、正对照试验。使用随机数字表将143例患者分配到ZYXH组或ZSQG组。ZYXH组给予ZYXH每日3次,连续6个月;ZSQG组给予ZSQG每日3次,连续6个月。乳核直径;子宫、卵巢和最大卵泡测量结果;比较两组患者治疗3个月、6个月时的中医症状分型评分。结果治疗3个月后,两组乳腺核指数变化差异无统计学意义(左3.4±3.1 vs 3.5±3.1,P = 0.790;右侧3.0±2.9 vs 3.6±3.0,P = 0.719)。ZYXH组子宫体积小于ZSQG组(2.1±1.6 vs 2.6±2.2,P = 0.006)。双侧卵巢体积和最大卵泡直径组间差异无统计学意义(左侧卵巢体积:1.2±0.7 vs 1.3±0.6,P = 0.8;右侧1.2±0.7 vs 1.4±1.1,P = 0.984;最大卵泡直径:左侧3.9±1.7 vs 3.5±2.2,P = 0.158;右3.5±1.7 vs 3.9±2.1,P = 0.314)。结论zyxh颗粒和ZSQG颗粒均能影响PPP女孩乳腺核的大小,改善其中医证型。ZYXH颗粒在子宫、卵巢和卵泡大小的减小方面比ZSQG颗粒略有优势。
期刊介绍:
Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.