A Review of Clinical Trial Studies on Medicinal Plants in the Treatment of Diabetes

B. Fallah, A. Mehrabbeik, N. Salmani
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Abstract

Objective: The use of medicinal plants in diabetic patients is rising, it is essential to increase knowledge about the effects of medicinal plants and subsequently perform evidence-based action, so, review studies are a helpful way for the present purpose. Current study was conducted to investigate the clinical trials of medicinal plants used in the treatment of diabetes in Iran. Materials and Methods: Articles published online between 2010 - 2020 were googled in Magiran, SID, Scopus, and, Iran Medex with Persian keywords such as “type 2 diabetes”, “medicinal herbs”, “healing herbs” “herbs”, “medicinal plants” and “clinical trial”. The inclusion criteria for articles were conducting in the form of a clinical trial, conducting in Iran, publishing in Persian language and having at least a score of 3 based on the Jadad scale. Results: 20 clinical trial studies were extracted. Five studies were conducted on cinnamon and two studies on cumin and the rest of the plants were examined just in one study. Although some trials showed positive effects of the medicinal plants on reducing fasting blood sugar (FBS) and glycosylated hemoglobin (HbA1c), some others demonstrated that medicinal plants had no effect on important variables in diabetes control. Conclusion: Conclusions about the benefits of plants should be made with caution, safety and efficacy of plants in the treatment of diabetes should be investigated further. It is essential that patients take any herbal supplements under physician’s supervision and after receiving the necessary advice.
药用植物治疗糖尿病的临床试验研究综述
目的:糖尿病患者对药用植物的使用正在增加,有必要增加对药用植物作用的认识,并随后采取循证行动,因此,综述研究是实现这一目的的一种有用方法。目前的研究是为了调查伊朗用于治疗糖尿病的药用植物的临床试验。材料和方法:2010年至2020年期间在线发表的文章在Magiran、SID、Scopus和Iran Medex上用波斯语关键词进行了谷歌搜索,如“2型糖尿病”、“草药”、“治疗药物”、“草本植物”、“药用植物”和“临床试验”。文章的纳入标准是以临床试验的形式进行,在伊朗进行,用波斯语发表,并且根据Jadad量表至少得3分。结果:提取了20项临床试验研究。在一项研究中,对肉桂进行了五项研究,对孜然和其他植物进行了两项研究。尽管一些试验表明药用植物对降低空腹血糖(FBS)和糖化血红蛋白(HbA1c)有积极作用,但其他一些试验表明,药用植物对糖尿病控制中的重要变量没有影响。结论:对植物治疗糖尿病的疗效和安全性应进一步研究。至关重要的是,患者在医生的监督下并在收到必要的建议后服用任何草药补充剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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25
审稿时长
26 weeks
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