Red Blood Cells Aggregation in the Patients with Type 2 Diabetes and T2D Associated Anemia, a Case Control Study in Bangladesh

Abstract

Abstract Background and Aims: Type 2 Diabetes (T2D) is a chronic metabolic disorder. Nowadays the number of people with diabetes mellitus is quadrupling in the world as well as in Bangladesh. It is related to different types of disease morbidity and sociodemographic parameters. The present study aimed to investigate the association of RBC aggregation (measured by ESR level) with T2D and T2D associated anemia. Material and method: A total of 234 subjects were included in the study. Sociodemographic and anthropometric information about study subjects were collected using a standard questionnaire. Blood samples were tested for random blood glucose levels, Hb percentage, and ESR. Association of these data with metabolic disorders was analyzed by statistical analysis software, SPSS. Results: This study provides a piece of evidence that anemia is highly prevalent in T2D patients than the healthy control subjects in Bangladesh (59.1% vs 22.5%; P value <0.001). The ESR values were significantly elevated in T2D patients as well as anemic and aged subjects (P value <0.001). Conclusion: The study thus suggests that anemia was prevalent in T2D patients in Bangladesh. The RBC aggregation was significantly elevated in patients with T2D as well as anemia, indicating increased inflammatory response in these diseases.