Complexes of Citrus Pectin with Nifedipine: Preparation and Physicochemical Properties

IF 1.1 4区化学 Q4 CHEMISTRY, PHYSICAL

Doklady Physical Chemistry Pub Date : 2023-05-24 DOI:10.1134/S0012501623700070

S. T. Minzanova, E. V. Chekunkov, A. V. Khabibullina, D. M. Arkhipova, L. G. Mironova, A. R. Khamatgalimov, V. A. Milyukov, V. F. Mironov

引用次数: 0

Abstract

Formation of stable complexes of pectin polysaccharides with Nifedipine hypotensive drug has been shown by IR and UV spectroscopy, stereochemistry of the complexes has been determined, their preparation conditions have been optimized. Features of thermal decomposition of pectin and the prepared complexes with Nifedipine have been studied by TGA/DSC. Obtained results provide scientific foundation to design new water-soluble non-toxic formulation of Nifedipine to expand the use of the drug in medicine.

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柑橘果胶与硝苯地平配合物的制备及其理化性质

用红外光谱和紫外光谱研究了果胶多糖与硝苯地平降血压药形成稳定的配合物，测定了配合物的立体化学性质，并对其制备条件进行了优化。采用热重分析/差示量热分析(TGA/DSC)研究了果胶的热分解特性及其与硝苯地平的配合物。所得结果为设计硝苯地平水溶性无毒新剂型，扩大该药物在医学上的应用提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Physical Chemistry 化学-物理化学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Physical Chemistry is a monthly journal containing English translations of current Russian research in physical chemistry from the Physical Chemistry sections of the Doklady Akademii Nauk (Proceedings of the Russian Academy of Sciences). The journal publishes the most significant new research in physical chemistry being done in Russia, thus ensuring its scientific priority. Doklady Physical Chemistry presents short preliminary accounts of the application of the state-of-the-art physical chemistry ideas and methods to the study of organic and inorganic compounds and macromolecules; polymeric, inorganic and composite materials as well as corresponding processes. The journal is intended for scientists in all fields of chemistry and in interdisciplinary sciences.