Organocatalytic Synthesis of γ-Amino Acid Precursors via Masked Acetaldehyde under Micellar Catalysis

Abstract

The development of micellar catalysis offers a sustainable alternative to organic solvents representing an environmental milestone in organic synthesis. Here the first Michael addition of masked acetaldehyde under neutral, cationic and anionic micellar catalysis is reported, affording the products in high yields and enantiomeric excess in spite the use of water as solvent.