First-line pemetrexed-platinum doublet chemotherapy with or without bevacizumab in non-squamous non-small cell lung cancer: A real-world propensity score-matched study in China

IF 7 2区 医学 Q1 ONCOLOGY
Fei Qi, Xingsheng Hu, Yutao Liu, Zhijie Wang, J. Duan, Jie Wang, M. Dong
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引用次数: 5

Abstract

Objective To evaluate the efficacy and safety profile of first-line bevacizumab (Bev)-containing pemetrexed-platinum chemotherapy in a real-world Chinese cohort with advanced non-squamous non-small cell lung cancer (NS-NSCLC). Methods A total of 415 eligible patients with NS-NSCLC who received first-line pemetrexed-platinum chemotherapy at National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between February 2010 and September 2017 were reviewed retrospectively: 309 Bev(−) and 106 Bev(+) cases. Bev was administered at 7.5 mg/kg every 3 weeks in the Bev(+) group. To reduce the risk of a selection bias, a propensity score-matching (PSM) was conducted and 105 pairs of Bev(−) and Bev(+) cases were identified. Results The median duration of follow-up was 15.8 months. The median progression-free survival (PFS) was prolonged significantly in the Bev(+) group than in the Bev(−) group in overall (9.8vs. 7.8 months, P=0.006) and PSM pairs (9.8 vs. 6.6 months, P<0.001). Moreover, patients receiving maintenance therapy with pemetrexed plus Bev had longer PFS than those interrupted after induction chemotherapy, or those receiving mono-maintenance with pemetrexed (12.3vs. 4.8 vs. 8.6 months; P<0.001). Multivariate analyses revealed Bev to be one of the favorable prognostic factors for PFS, along with the predictor of maintenance therapy. Conclusions First-line induction and maintenance therapy with Bev (7.5 mg/kg every 3 weeks) combined with pemetrexed-platinum chemotherapy was efficacious and superior to non-Bev chemotherapy in Chinese patients with advanced NS-NSCLC.
非鳞状非小细胞肺癌癌症中应用或不应用贝伐单抗的第一线培美曲塞-铂双联化疗:中国一项现实世界倾向评分匹配研究
目的评估含贝伐单抗(Bev)的培美曲塞铂类一线化疗在中国晚期非鳞状非小细胞肺癌癌症患者中的疗效和安全性。方法回顾性分析2010年2月至2017年9月在国家癌症中心/国家癌症临床研究中心/癌症医院、中国医学科学院和北京协和医学院接受一线培美曲塞铂类化疗的415例符合条件的NS-NSCLC患者:309例Bev(−)和106例Bev(+)。Bev(+)组每3周给药7.5mg/kg。为了降低选择偏差的风险,进行了倾向评分匹配(PSM),并确定了105对Bev(−)和Bev(+)病例。结果中位随访时间为15.8个月。Bev(+)组的中位无进展生存期(PFS)总体上比Bev(−)组显著延长(9.8个月对7.8个月,P=0.006)和PSM对(9.8对6.6个月,P<0.001)。此外,接受培美曲塞加Bev维持治疗的患者的PFS比诱导化疗后中断的患者更长,或接受培美曲塞单次维持治疗的患者(12.3个月vs.4.8个月vs.8.6个月;P<0.001)。多因素分析显示,Bev是PFS的有利预后因素之一,也是维持治疗的预测因素。结论Bev(每3周7.5mg/kg)联合培美曲塞铂类化疗一线诱导维持治疗晚期NS-NSCLC疗效显著,优于非Bev化疗。
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来源期刊
自引率
9.80%
发文量
1726
审稿时长
4.5 months
期刊介绍: Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.
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