Evaluation of terpene-based hydrophobic deep eutectic solvents as skin permeation enhancers

IF 1.7 4区物理与天体物理 Q3 PHYSICS, APPLIED

Japanese Journal of Applied Physics Pub Date : 2023-01-16 DOI:10.35848/1347-4065/acb392

Yuta Araki, Yuma Hamada, Norika Imamura, Koki Yamasaka, M. Sakuragi

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引用次数: 3

Abstract

We investigated whether carboxylic acid-terpene-based deep eutectic solvents (DESs) can be used as skin permeation enhancers. We performed transdermal experiments, and their results showed that DESs with longer hydrocarbon chains can enhance the skin permeability of hydrophilic fluorescein sodium and hydrophobic meloxicam. Additionally, all DESs could improve the skin permeability of poorly soluble resveratrol. Subsequently, we evaluated the stratum corneum’s structural transition after applying DESs. The results showed that the l-menthol-based DESs with longer hydrocarbon chains disrupt lipid layers more than those with shorter hydrocarbon chains. Thymol-based DES extracted the lipids in the stratum corneum and permeated the corneocytes. Transepidermal water loss measurements showed that l-menthol-based DESs with longer hydrocarbon chains and thymol-based DESs damage skin as they disturb the inner parts of stratum corneum lipids. Overall, we concluded that DESs with longer hydrocarbon chains can be used as skin permeation enhancers for various drugs by reducing skin irritation.

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萜烯基疏水性深共晶溶剂作为皮肤渗透促进剂的评价

我们研究了基于羧酸萜烯的深度共晶溶剂（DESs）是否可以用作皮肤渗透促进剂。我们进行了透皮实验，结果表明，具有较长烃链的DESs可以增强亲水性荧光素钠和疏水性美洛昔康的皮肤渗透性。此外，所有的DES都可以改善难溶性白藜芦醇的皮肤渗透性。随后，我们评估了应用DESs后角质层的结构转变。结果表明，具有较长烃链的基于l-薄荷醇的DESs比具有较短烃链的DESs更能破坏脂质层。基于胸腺素的DES提取角质层中的脂质并渗透到角质细胞中。经表皮水分损失测量表明，具有较长烃链的基于l-薄荷醇的DESs和基于百里香酚的DESs会破坏角质层脂质的内部，从而损害皮肤。总之，我们得出的结论是，具有较长烃链的DESs可以通过减少皮肤刺激，用作各种药物的皮肤渗透促进剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Applied Physics 物理-物理：应用

CiteScore

3.00

自引率

26.70%

发文量

818

审稿时长

3.5 months

期刊介绍： The Japanese Journal of Applied Physics (JJAP) is an international journal for the advancement and dissemination of knowledge in all fields of applied physics. JJAP is a sister journal of the Applied Physics Express (APEX) and is published by IOP Publishing Ltd on behalf of the Japan Society of Applied Physics (JSAP). JJAP publishes articles that significantly contribute to the advancements in the applications of physical principles as well as in the understanding of physics in view of particular applications in mind. Subjects covered by JJAP include the following fields: • Semiconductors, dielectrics, and organic materials • Photonics, quantum electronics, optics, and spectroscopy • Spintronics, superconductivity, and strongly correlated materials • Device physics including quantum information processing • Physics-based circuits and systems • Nanoscale science and technology • Crystal growth, surfaces, interfaces, thin films, and bulk materials • Plasmas, applied atomic and molecular physics, and applied nuclear physics • Device processing, fabrication and measurement technologies, and instrumentation • Cross-disciplinary areas such as bioelectronics/photonics, biosensing, environmental/energy technologies, and MEMS