Formulation and Characterization of Raloxifene loaded Biodegradable Polymeric Nanomicelles

Abstract

Raloxifene has been used to treat breast cancer; nevertheless, it has poor water solubility and a low bioavailability fraction because higher fi rst-pass metabolism hinders its application raloxifene nano micelles by using PLGA50:50 to enhance solubility and bioavailability. The solvent evaporation technique was used to prepare polymeric nano-micelles. Ral-loaded polymeric micelles had a zeta potential of - 0.71 mV, implying a practically neutral surface charge. Blank micelles and RAL-loaded micelles had similar average sizes of 84.29 nm and 95.41 nm, respectively. The drug encapsulating and drug loading capacity was found to be 16.08 ± 0.34% and drug loading 5.04 ± 0.002% (w/w), respectively. An in-vitro study illustrates a 95.10% sustained release drug profi le for 120 hours.