Traditional Medicine Based Drug Development

P. Perera
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Abstract

Currently few of traditional medicines have been developed by blending basic sciences and technologies up to the clinical usage. In future standard traditional medicine based botanical therapeutics will be important in biomedicine developments due to economic background in most parts of the world. Today there are many basic experimental research have being doing for plant based materials. But very limited data can be founded for evidence based use of those experimented plant materials in clinical setup. Therefore this is the high time for develop effective evidence based traditional medicine system in the world. This can be done by evaluating traditional medicine remedies for their pharmacodynamics, pharmacokinetics, stability, shelf life and toxicity par with current standards. Challenge of reproducibility and consistency of herbal remedies can be achieved by developing standard assay markers and chemiinformatic approaches. Further conventional concepts of clinical research design methods may not be adequate when evaluating and conducting clinical trials for traditional medicine. Therefore needs to identifying traditional medicine concepts and develop research strategies for achieve full benefits of these medicine systems. Further there is need to develop and validate a range of parameters applicable to modern and traditional medicines in the light of basic sciences like biochemistry and molecular biology.
以传统医学为基础的药物开发
目前,很少有传统药物是通过将基础科学和技术融合到临床应用上来开发的。由于世界大多数地区的经济背景,未来以传统医学为基础的标准植物疗法将在生物医学发展中发挥重要作用。今天,有许多基于植物的材料的基础实验研究正在进行中。但是,在临床设置中基于证据使用这些实验植物材料的数据非常有限。因此,现在正是在世界范围内建立有效的循证传统医学体系的时候。这可以通过评估传统药物的药效学、药代动力学、稳定性、保质期和毒性来达到目前的标准。草药的再现性和一致性的挑战可以通过开发标准测定标记物和化学信息学方法来实现。在评估和进行传统医学的临床试验时,临床研究设计方法的进一步传统概念可能不够充分。因此,需要明确传统医学的概念,制定研究策略,以充分发挥这些医学体系的优势。此外,需要根据生物化学和分子生物学等基础科学,开发和验证适用于现代和传统药物的一系列参数。
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