Acid Suppressive Drugs

C. Shin
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引用次数: 1

Abstract

Histamine H2 receptor antagonists (H2RAs) suppress gastric acid production by blocking H2 receptors in parietal cells. Studies have shown that proton pump inhibitors (PPIs) are superior to H2RAs as a treatment for acid-related disorders, such as peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). PPIs reduce gastric acid production by irreversibly inhibiting the H+/K+ ATPase pump, and they also increase gastric emptying. Although PPIs have differing pharmacokinetic properties, each PPI is effective in managing GERD and PUDs. However, PPIs have some limitations, including short plasma half-lives, breakthrough symptoms (especially at night), meal-associated dosing, and concerns associated with long-term PPI use. Potassium-competitive acid blockers (P-CABs) provide more rapid and profound suppression of intragastric acidity than PPIs. P-CABs are non-inferior to lansoprazole in healing erosive esophagitis and peptic ulcers, and may also be effective in improving symptoms in patients with non-erosive reflux disease. Acid suppressive drugs are the most commonly used drugs in clinical practice, and it is necessary to understand the pharmacological properties and adverse effects of each drug.
抑酸药物
组胺H2受体拮抗剂(H2RA)通过阻断壁细胞中的H2受体来抑制胃酸的产生。研究表明,质子泵抑制剂(PPIs)在治疗酸性相关疾病方面优于H2RA,如消化性溃疡病(PUD)和胃食管反流病(GERD)。PPIs通过不可逆地抑制H+/K+ATP酶泵来减少胃酸的产生,并增加胃排空。尽管PPI具有不同的药代动力学特性,但每种PPI在管理GERD和PUD方面都是有效的。然而,PPI有一些局限性,包括血浆半衰期短、突破性症状(尤其是在夜间)、与膳食相关的给药以及与长期使用PPI相关的担忧。钾竞争性酸阻滞剂(P-CABs)比PPIs对胃内酸度的抑制更快、更深入。P-CABs在治疗侵蚀性食管炎和消化性溃疡方面不劣于兰索拉唑,也可能有效改善非侵蚀性反流疾病患者的症状。抑酸药物是临床上最常用的药物,有必要了解每种药物的药理特性和不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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41
审稿时长
18 weeks
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