Harnessing the microbiota to treat neurological diseases


IF 8.3 2区 医学 Q1 Medicine
N. Surana
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引用次数: 2

Abstract

Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota—the collection of commensal organisms that live in and on each of us—contributes to nearly every facet of host physiology, from ontogeny of the immune system to neurological function to metabolism. Although the specific details of these host–microbe interactions are still being elucidated for most diseases, the coupling of clinical samples with animal models of disease have provided key insights. This review provides some general background on the microbiota, highlights a few examples of how the microbiota influences diseases of the central nervous system, and provides a perspective for how these findings may be clinically translatable.

利用微生物群治疗神经系统疾病
过去十年的研究改变了我们以前对微生物的简单看法,即微生物在疾病中只起致病作用,使我们更加坚定地认识到它们对维持人类健康至关重要。事实上,我们的微生物群——生活在我们每个人体内和身上的共生生物的集合——几乎对宿主生理学的各个方面都有贡献,从免疫系统的个体发育到神经功能再到新陈代谢。尽管大多数疾病的宿主-微生物相互作用的具体细节仍在阐明中,但临床样本与疾病动物模型的结合提供了关键的见解。这篇综述提供了微生物群的一些一般背景,重点介绍了微生物群如何影响中枢神经系统疾病的几个例子,并为这些发现如何在临床上可翻译提供了一个视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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