An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides – part II: Synthetic studies on complex arabinofuranosyl oligosaccharides carrying other functional motifs and related derivatives and analogs

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-01-01 DOI:10.1080/07328303.2019.1630840

Liwen Han , Lizhen Wang , Zhongwu Guo

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引用次数: 7

Abstract

Abstract Lipoarabinomannan (LAM), mannosyl LAM (ManLAM), and mycolyl-arabinogalactan (mAG) are unique and ubiquitous cell wall constituents of Mycobacterium tuberculosis (M. tb), the bacterium causing tuberculosis (TB). It has been well documented that LAM, ManLAM, and mAG play an important role in mycobacterial infections and in the elicitation of specific immune responses against M. tb in the host. Therefore, LAM, ManLAM, mAG, and related molecules are attractive targets for the development of novel TB diagnostic and therapeutic strategies. Accordingly, numerous research groups have spent great effort on the chemical synthesis and biological studies of mycobacterium-related arabinofuranosyl oligosaccharides and their mimetics and conjugates. This article provides an extensive review about the progresses in this area. Due to the page limit of this journal, the review is published in three parts separately. This part (Part II) is focused on the synthesis of various ManLAM and mAG analogs containing mannose, galactose or galactosamine units and other natural structural motifs, as well as arabinofuranosyl oligosaccharide C-analogs and other derivatives. Graphical Abstract

查看原文本刊更多论文

分枝杆菌细胞壁多糖相关低聚糖研究综述——第二部分:携带其他功能基序的复合阿拉伯糖糠基低聚糖及其衍生物和类似物的合成研究

脂阿拉伯甘露聚糖(LAM)、甘露甘露聚糖(ManLAM)和真菌素-阿拉伯半乳聚糖(mAG)是结核分枝杆菌(M. tb)的独特和普遍存在的细胞壁成分。结核分枝杆菌是引起结核病的细菌。已有文献证明LAM、ManLAM和mAG在分枝杆菌感染中发挥重要作用，并在宿主体内引发针对结核分枝杆菌的特异性免疫反应。因此，LAM、ManLAM、mAG及其相关分子是开发新型结核病诊断和治疗策略的有吸引力的靶点。因此，许多研究小组对与分枝杆菌相关的阿拉伯糖脲基低聚糖及其模拟物和偶联物的化学合成和生物学研究付出了巨大的努力。本文对这一领域的进展进行了广泛的综述。由于本刊页数限制，本综述分三部分分别发表。本部分(第二部分)主要是合成各种含有甘露糖、半乳糖或半乳糖胺单元等天然结构基序的ManLAM和mAG类似物，以及阿拉伯糖醛基低聚糖c类似物等衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.