Lipids and apolipoproteins C-III and E among treatment-naïve and treatment-experienced persons with HIV in Nigeria.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2023-07-17 eCollection Date: 2023-01-01 DOI:10.4102/ajlm.v12i1.2018
Mercy N Okunorobo, Nwakasi K Nnamah, Ugomma A Ude, Enyioma A Ude
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引用次数: 0

Abstract

Background: Dyslipidaemia is a known cause of cardiovascular mortality. Persons living with HIV are at high risk of developing cardiovascular disease due to lipid metabolism disorders associated with HIV or its therapy.

Objective: This study evaluated concentrations of lipoproteins and apolipoprotein C-III and E, as a way of assessing cardiometabolic risks among HIV patients.

Methods: We enrolled 50 HIV-negative persons and 100 HIV-positive patients, 50 on antiretroviral therapy (ART) and 50 treatment-naïve persons, from the Central Hospital and the Stella Obasanjo Hospital, Benin City, Edo State, Nigeria, between May 2015 and November 2015. Participants with a history of metabolic abnormalities were excluded. Apolipoproteins were assessed by enzyme-linked immunosorbent assay, while lipids were measured by spectrophotometry.

Results: There were significant abnormalities in the lipid profile of patients with HIV. Triglycerides levels of HIV patients (ART-naïve: 1.44 ± 0.65 mmol/L; p < 0.001 and ART-experienced: 1.49 ± 0.70 mmol/L; p = 0.001) were significantly higher than among controls (0.95 ± 0.54 mmol/L). HIV patients had higher concentrations of apolipoprotein C-III than controls (p < 0.001) and higher low-density lipoprotein cholesterol levels (treatment-naïve: 2.83 mmol/L and ART-experienced patients: 3.59 mmol/L) than controls (2.50 mmol/L; p = 0.003). Conversely, HIV patients had significantly lowered high-density lipoprotein cholesterol levels compared to controls (p < 0.001).

Conclusion: Dyslipidaemia was observed among HIV participants, irrespective of their ART experience. Therefore, it is crucial that the lipids of HIV patients be closely monitored to enable early intervention and decrease cardiovascular death.

What this study adds: This study affirms that dyslipidemia is a complication of HIV or the prolonged use of ART.

尼日利亚治疗初期和有治疗经验的艾滋病毒感染者的脂质和载脂蛋白C-III和E
背景:血脂异常是已知的心血管死亡原因。由于与艾滋病毒或其治疗相关的脂质代谢紊乱,艾滋病毒感染者患心血管疾病的风险很高。目的:本研究评估了脂蛋白和载脂蛋白C-III和E的浓度,作为评估HIV患者心脏代谢风险的一种方法。方法:我们在2015年5月至2015年11月期间招募了来自尼日利亚埃多州贝宁市中央医院和Stella Obasanjo医院的50名HIV阴性患者和100名HIV阳性患者,50名接受抗逆转录病毒疗法(ART)的患者和50名治疗幼稚的患者。有代谢异常史的参与者被排除在外。载脂蛋白采用酶联免疫吸附法测定,脂质采用分光光度法测定。结果:HIV感染者的血脂谱存在明显异常。HIV患者的甘油三酯水平(早期抗逆转录病毒疗法:1.44±0.65 mmol/L;p 0.001和经历过抗逆转录病毒治疗:1.49±0.70 mmol/L,p=0.001)显著高于对照组(0.95±0.54 mmol/L)。HIV患者的载脂蛋白C-III浓度高于对照组(p 0.001),低密度脂蛋白胆固醇水平(治疗初期:2.83 mmol/L,有ART经验的患者:3.59 mmol/L)高于对照组。相反,与对照组相比,HIV患者的高密度脂蛋白胆固醇水平显著降低(p 0.001)。结论:在HIV参与者中观察到血脂异常,无论他们的ART经历如何。因此,密切监测HIV患者的血脂以进行早期干预并减少心血管死亡至关重要。这项研究补充道:这项研究证实,血脂异常是HIV或长期使用ART的并发症。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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