A Study of Absorption and Selected Molecular Physicochemical Properties of Some Antipsychotic Drugs

Q3 Medicine

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-10-14 DOI:10.2478/sjecr-2020-0004

J. Odovic

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引用次数: 0

Abstract

Abstract Antipsychotic drugs are commonly prescribed for different mental disorders and can be classified into two main groups: the first which contain originally developed antipsychotics of the first generation or typical antipsychotics and the other group with newly developed antipsychotics or atypical antipsychotics of the second generation. In this study, eleven antipsychotic drugs (chlorpromazine, flupentixol, haloperidol, zuclopenthixol, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone) were investigated to evaluate significance of their molecular physicochemical properties (lipophilicity, aqueous solubility, polar surface area, molecular weight, volume value and acidity) for their bioavailability. Relationships between literature available intestinal absorption data of antipsychotic drugs and their lipophilicity descriptor with one additional molecular descriptor, investigated using multiple linear regression analysis provided high correlations for molecular descriptors, Mw, Vol, pKa, as additional independent variables. Values of correlation coefficients (R2) were ranged from 0.951 (for Vol) above 0.944 (for Mw) to 0.923 (for pKa).

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一些抗精神病药物的吸收及分子物理化学性质的研究

摘要抗精神病药物通常用于治疗不同的精神障碍，可分为两大类：第一类含有最初开发的第一代抗精神病药或典型抗精神病剂，另一类含有新开发的第二代抗精神疾病药或非典型抗精神病物。在本研究中，研究了11种抗精神病药物（氯丙嗪、氟戊醇、氟哌啶醇、左氯戊异醇、阿立哌唑、氯氮平、奥氮平、喹硫平、利培酮、舍吲哚、齐拉西酮）的分子物理化学性质（亲脂性、水溶性、极性表面积、分子量、体积值和酸度）对其生物利用度的意义。使用多元线性回归分析研究的抗精神病药物的文献可用肠道吸收数据与其亲脂性描述符和一个额外分子描述符之间的关系，为分子描述符Mw、Vol、pKa作为额外自变量提供了高度相关性。相关系数（R2）的值范围从0.951（对于Vol）到0.944（对于Mw）到0.923（对于pKa）。

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来源期刊

Serbian Journal of Experimental and Clinical Research Medicine-Medicine (all)

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Serbian Journal of Experimental and Clinical Research is a peer-reviewed, general biomedical journal. It publishes original basic and clinical research, clinical practice articles, critical reviews, case reports, evaluations of scientific methods, works dealing with ethical and social aspects of biomedicine as well as letters to the editor, reports of association activities, book reviews, news in biomedicine, and any other article and information concerned with practice and research in biomedicine, written in the English.