Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2017-02-01 DOI:10.9758/cpn.2017.15.1.64

Mei Han, Ji-chun Zhang, K. Hashimoto

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引用次数: 25

Abstract

Objective Prenatal infection is implicated in the etiology of schizophrenia. The objective of this paper is to study the role of complement protein C1q in the psychosis of adult offspring after maternal immune activation (MIA). In addition, effect of 7,8-dihydroxyflavone (7,8-DHF: a tropomyosin receptor kinase B [TrkB] agonist) was also examined. Methods Western blot analysis of C1q in the brain regions from adult offspring after prenatal poly(I:C) (5.0 mg/kg/day from E12 to E17) exposure was performed. 7,8-DHF or vehicle was given from 4 to 8-weeks old. Results Expression of C1q in the prefrontal cortex (PFC) of adult offspring from poly(I:C)-treated pregnant mice was significantly higher than that of control group. Early treatment with 7,8-DHF during juvenile and adolescent stages could prevent an increase of C1q in the PFC of adult offspring after MIA. Conclusion Therefore, it is likely that increased C1q expression in the frontal cortex may play a role in the behavioral abnormalities of adult offspring after MIA. Furthermore, supplementation with a TrkB agonist such as 7,8-DHF during the prodromal stage may have prophylactic effects on the behavioral abnormalities after MIA.

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母体免疫激活后成年后代前额皮质C1q水平升高:7,8-二羟黄酮的预防作用

目的产前感染与精神分裂症的病因有关。本文的目的是研究补体蛋白C1q在母体免疫激活（MIA）后成年后代精神病中的作用。此外，还检测了7,8-二羟基黄酮（7,8-DHF：原肌球蛋白受体激酶B[TrkB]激动剂）的作用。方法采用Western blot方法对出生前poly（I:C）（从E12到E17为5.0mg/kg/天）暴露后成年后代脑区C1q进行分析。7，8-DHF或载体给药4至8周龄。结果poly（I:C）处理的孕鼠成年后代前额叶皮层C1q的表达显著高于对照组。在青少年期早期使用7,8-DHF治疗可以防止MIA后成年后代PFC中C1q的增加。结论因此，额叶皮层C1q表达的增加可能在MIA后成人后代的行为异常中发挥作用。此外，在前驱期补充TrkB激动剂如7,8-DHF可能对MIA后的行为异常具有预防作用。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.