In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2019-04-14 DOI:10.3329/BJP.V14I2.38870

Khadija Bouabid, F. Lamchouri, H. Toufik, Mohamed Boulfia, S. Senhaji, M. Faouzi

引用次数: 8

Abstract

The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of A. gummifera was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal. Video Clip of Methodolpogy: 5 min 53 sec: Full Screen Alternate

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白术水浸和甲醇浸提液的体内抗糖尿病作用

已在2型糖尿病小鼠模型中评估了白术（摩洛哥传统医学中使用的植物）的抗糖尿病作用。将小鼠分为五组：正常对照组、糖尿病对照组、用水性浸渍物（500mg/kg）治疗的糖尿病组、用甲醇浸渍物（5mg/kg）治疗的血糖组和用二甲双胍（300mg/kg）处理的血糖组。小鼠的治疗通过每天灌胃进行，持续5周。每周通过禁食葡萄糖对小鼠进行监测，并在治疗结束时测量生化参数。树胶水浸液对糖尿病小鼠的空腹血糖降低效果最好，达62.7%，使糖尿病小鼠的生化指标恢复正常。方法的视频剪辑：5分53秒：全屏交替

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.