Anaphylaxis to drug excipients

Q3 Medicine

Allergo Journal International Pub Date : 2022-05-31 DOI:10.1007/s40629-022-00214-9

Wolfgang Pfützner

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引用次数: 0

Abstract

Summary

In addition to the therapeutic agent, drugs contain excipients such as stabilizers, preservatives, solubilizers, or dyes, some of which are identical to additives in foods. Anaphylaxis to these excipients is probably an underestimated problem. After the first descriptions of anaphylactic reactions to drug excipients appeared more than 30 years ago, the number of corresponding reports has increased significantly over the years. However, a diagnostic gap exists in the clarification of drug allergic reactions when the index product is not known and/or is not available for testing. In the present work, individual excipients are presented as examples for which publications on anaphylaxis are available. Furthermore, the options of allergological testing both in vivo and in vitro are discussed. The pathogenesis of such reactions is still unresolved in many cases, and current concepts are briefly presented in the conclusion. With increasing knowledge about anaphylaxis to drug excipients, it is assumed that these can then be recognized more often and diagnostically clarified.

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对药物辅料的过敏反应

摘要除了治疗剂外，药物还含有辅料，如稳定剂、防腐剂、增溶剂或染料，其中一些与食品中的添加剂相同。对这些赋形剂的过敏可能是一个被低估的问题。在30多年前首次出现对药物赋形剂过敏反应的描述后，多年来相应的报告数量显著增加。然而，当指标产品未知和/或无法进行测试时，在澄清药物过敏反应方面存在诊断空白。在目前的工作中，个别赋形剂作为例子，可获得关于过敏反应的出版物。此外，还讨论了体内和体外过敏性试验的选择。在许多情况下，这种反应的发病机制仍未解决，结论中简要介绍了当前的概念。随着对药物赋形剂过敏反应的了解不断增加，人们认为这些过敏反应可以更频繁地被识别并在诊断上得到澄清。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergo Journal International Medicine-Immunology and Allergy

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.