Correlation between serum cytokine levels and cognitive function in patients with bipolar I manic episode

中华行为医学与脑科学杂志 Pub Date : 2020-01-20 DOI:10.3760/CMA.J.CN371468-20190916-00621

Zhongxian Wang, Ai-guo Zhang, Yang Xu, Wenzhi Pei, Jie Chen, Xulai Zhang

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引用次数: 0

Abstract

Objective To explore the relationship between serum cytokine levels and cognitive impairment in patients with bipolar I manic episode. Methods Forty-four patients with bipolar I manic episode (BDI group) and 42 healthy volunteers (HC group) matched with demographic data were included.Peripheral serum interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-23 (IL-23), and tumor necrosis factor-α (TNF-α) levels were detected by enzyme-linked immunosorbent assay (ELISA). The repeatable battery for the assessment of neuropsychological status (RSPM) was used to evaluate the cognitive function of the two groups.Young manic rating scale (YMRS) was used to evaluate the clinical manic symptoms of patients.Hypothesis testing and correlation analysis were processed by SPSS 22.0. Results (1) The expression levels of serum cytokines IL-6, IL-10, IL-23 and TNF-α in BDI group ((38.872±7.803), (33.259±7.260), 42.350(33.600, 55.390), (108.309±19.398)) were significantly different with those in HC group ((24.664±6.083), (29.257±5.208), 17.360(12.870, 30.690), (68.674±13.610)), and the differences were statistically significant ((t=9.387, t=2.947, Z=-5.477, t=10.921, all P 0.05). Conclusion Patients with bipolar I disorder manic have changes in serum levels of cytokines and cognitive dysfunction. The course of disease and cognitive function are related with serum cytokine level. Key words: Bipolar disorder type I; Manic episode; Cytokines; Repetitive set of neuropsychological state tests

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双相I型躁狂发作患者血清细胞因子水平与认知功能的相关性

目的探讨双相I型躁狂发作患者血清细胞因子水平与认知障碍的关系。方法纳入44例双相I型躁狂发作患者（BDI组）和42名符合人口统计学数据的健康志愿者（HC组）。采用酶联免疫吸附法（ELISA）检测外周血白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、白介素-23（IL-23）和肿瘤坏死因子-α（TNF-α）水平。使用可重复的神经心理状态评估组（RSPM）来评估两组的认知功能。采用青年躁狂评定量表（YMRS）评定患者临床躁狂症状。采用SPSS 22.0进行假设检验和相关分析。结果（1）BDI组血清细胞因子IL-6、IL-10、IL-23和TNF-α的表达水平分别为（38.872±7.803）、（33.259±7.260）、42.350（33.600，55.390）、（108.309±19.398），与HC组（24.664±6.083）、（29.257±5.208）、17.360（12.870，30.690）、（68.674±13.610），差异有统计学意义（t=9.387，t=2.947，Z=5.477，t=10.921，均P<0.05）。病程和认知功能与血清细胞因子水平有关。关键词：双相情感障碍I型；躁狂发作；细胞因子；重复性神经心理状态测试

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来源期刊

中华行为医学与脑科学杂志

自引率

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发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.