Effect of Early Continuous Veno-Venous Haemofiltration in Severe Acute Pancreatitis for the Prevention of Local Pancreatic Complications

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Research and Practice Pub Date : 2022-03-07 DOI:10.1155/2022/7575231

S. Yadav, Bing Zhang

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引用次数: 3

Abstract

Objective To compare the conventional treatment and continuous veno-venous haemofiltration (CVVH) in severe acute pancreatitis (SAP) for the prevention of pseudocyst and walled-off necrosis. Patients and Methods. Forty-two patients were divided into two treatment groups: conventional treatment group contained 24 patients and CVVH had 18. Conventional treatment group patients were treated symptomatically and according to the causes. CVVH group patients were treated symptomatically, and CVVH was done within 2 hours of admission. Results In both groups, there was a decrease in amylase, lipase, CRP, IL-6, IL-10, TNF-alpha, Ranson score, Balthazar score, and APACHE-II score after 72 hours, but the decrease was significantly greater in CVVH patients. There were no any local pancreatic complications in CVVH patients, but 1 patient had an acute peripancreatic fluid collection, 2 patients had pseudocyst, and 2 patients had walled-off necrosis (WON), and a mortality one was seen in the conventional treatment group. Conclusion The present study shows that early CVVH may be able to prevent the formation of pseudocyst and win in SAP patients.

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重症急性胰腺炎早期持续静脉-静脉血液滤过对预防局部胰腺并发症的作用

目的比较常规治疗和连续静脉-静脉血液滤过（CVVH）治疗重症急性胰腺炎（SAP）预防假性囊肿和坏死的疗效。患者和方法。42例患者分为两组：常规治疗组24例，CVVH组18例。常规治疗组患者根据症状和病因进行治疗。CVVH组患者接受症状治疗，并在入院后2小时内进行CVVH。结果72小时后，两组患者的淀粉酶、脂肪酶、CRP、IL-6、IL-10、TNF-α、Ranson评分、Balthazar评分和APACHE-II评分均下降，但CVVH患者的下降幅度更大。CVVH患者没有任何胰腺局部并发症，但1例患者出现急性胰周积液，2例患者出现假性囊肿，2例出现壁坏死（WON），常规治疗组出现1例死亡。结论早期CVVH可预防SAP患者假性囊肿的形成，有利于SAP患者的生存。

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来源期刊

Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.