Vagus nerve stimulation for the treatment of heart failure

Z. Asad, S. Stavrakis
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引用次数: 4

Abstract

Heart failure (HF) is one of the most prevalent cardiovascular diseases and is associated with high morbidity and mortality. Mechanistically, HF is characterized by an overactive sympathetic nervous system and parasympathetic withdrawal, and this autonomic imbalance contributes to the progression of the disease. As such, modulation of autonomic nervous system by device-based therapy is an attractive treatment target. In this review, we discuss the role of autonomic nervous system dysfunction in the pathogenesis of HF and present the available evidence regarding vagus nerve stimulation for HF, with special emphasis on optimization of stimulation parameters. Finally, we discuss future avenues of research for neuromodulation in patients with HF.
迷走神经刺激治疗心力衰竭
心力衰竭(HF)是最常见的心血管疾病之一,与高发病率和死亡率有关。从机制上讲,HF的特征是交感神经系统过度活跃和副交感神经退缩,这种自主神经失衡导致了疾病的进展。因此,通过基于设备的治疗来调节自主神经系统是一个有吸引力的治疗目标。在这篇综述中,我们讨论了自主神经系统功能障碍在HF发病机制中的作用,并提出了迷走神经刺激治疗HF的可用证据,特别强调了刺激参数的优化。最后,我们讨论了HF患者神经调控的未来研究途径。
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