Production rate of heterocyclic compounds iodinated N-(p-chlorophenyl)-3,5- dimethyl-1,1-dioxo-1,2-thiazine

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI:10.4314/bcse.v37i5.16

Shireen Ibrahim Hamadamin

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Abstract

ABSTRACT. Iodinated heterocyclic molecules are crucial structural components of many natural products, including hormones, vitamins, and medicines. The pharmaceutical survey is very interested in the investigation of the kinetics of the iodination of N-(p-chlorophenyl)-3,5-dimethyl-1,1-dioxo-1,2-thiazine. The rate of iodination is directly dependent on the concentration of both 1,2-thiazine and iodine under different molar ratios (1:10), (10:1) adopted on the isolation method, the observed rate of iodination, the pseudo-first-order and the second order using (1:1) molar ratio in the overall reaction using spectrophotometric techniques. Thermodynamic activation parameters activation energy Ea, enthalpy change ΔH#, entropy change ΔS#, and Gibbs free energy ΔG# of activation were calculated from the rate constant at temperatures 273, 283, 293, 303, and 318 K. KEY WORDS: Production rate, 1,2-Thiazine, Iodine (I2), Kinetic Bull. Chem. Soc. Ethiop. 2023, 37(5), 1253-1262. DOI: https://dx.doi.org/10.4314/bcse.v37i5.16

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碘化N-（对氯苯基）-3,5-二甲基-1,1-二氧-1,2-噻嗪杂环化合物的产率

摘要。碘杂环分子是许多天然产物的重要结构成分，包括激素、维生素和药物。药学调查对研究N-（对氯苯基）-3,5-二甲基-1,1-二氧代-1,2-噻嗪的碘化动力学非常感兴趣。碘化速率直接取决于分离方法中采用的不同摩尔比（1:10）、（10:1）下1,2-噻嗪和碘的浓度、观察到的碘化速率、使用分光光度技术的总反应中使用（1:1）摩尔比的伪一级和二级碘化速率。热力学活化参数活化能Ea、焓变ΔH#、熵变ΔS#和吉布斯自由能ΔG#由273、283、293、303和318 K温度下的速率常数计算。关键词：生产率、1,2-噻嗪、碘（I2）、动力学公牛。化学。Soc.Ethiop。2023，37（5），1253-1262。DOI:https://dx.doi.org/10.4314/bcse.v37i5.16

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.