APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES

Q3 Medicine

Biomedical Photonics Pub Date : 2018-06-25 DOI:10.24931/2413-9432-2018-7-2-4-12

M. Kholodtsova, P. Grachev, W. Blondel, P. Zelenkov, Alexander A. Potapov, I. Shcherbakov, V. Loschenov

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引用次数: 4

Abstract

The abilities of the optical probe for fluorescence-guided stereotactic biopsy were investigated by means of a multifiber probe under 532 or 632.8 nm excitation. The set of multilayered phantoms representing a border between normal brain-tissue and a tumor with photosensitizer and gold nanoparticles (spheres or stars) in different concentrations were made to investigate the macroscopic parameters observed during the neurosurgical biopsy sample collection by means of the optical probe. These investigantions will allow to define the border of a brain tumor and control the type of tissue being collected by a stereotactic cannula during surgery. The impact of gold nanospheres and gold nanostars added in different concentrations to the bottom-layer of phantom was analyzed by fluorescence quenching or enhancement due to energy transfer between nanoparticles and fluorescent molecules. The results allow determining the tumor border and to make the biopsy uptake more efficient by observing the character of signal change while penetrating a tumor and while going out of it.

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空间分辨光谱器件的应用&以含金属纳米粒子的双层体模为例

利用多纤维探针在532或632.8nm激发下研究了光学探针用于荧光引导立体定向活检的能力。制作了一组多层模型，代表正常脑组织和肿瘤之间的边界，其中含有不同浓度的光敏剂和金纳米颗粒（球体或星形），以研究通过光学探针收集神经外科活检样本期间观察到的宏观参数。这些研究将允许定义脑肿瘤的边界，并控制手术期间立体定向套管收集的组织类型。通过纳米颗粒和荧光分子之间的能量传递引起的荧光猝灭或增强，分析了以不同浓度添加到体模底层的金纳米球和金纳米星的影响。该结果允许通过观察穿透肿瘤和离开肿瘤时信号变化的特征来确定肿瘤边界，并使活检吸收更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Photonics Medicine-Surgery

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The main goal of the journal – to promote the development of Russian biomedical photonics and implementation of its advances into medical practice. The primary objectives: - Presentation of up-to-date results of scientific and in research and scientific and practical (clinical and experimental) activity in the field of biomedical photonics. - Development of united Russian media for integration of knowledge and experience of scientists and practitioners in this field. - Distribution of best practices in laser medicine to regions. - Keeping the clinicians informed about new methods and devices for laser medicine - Approval of investigations of Ph.D candidates and applicants.