Prescription patterns of analgesics, antipyretics, and non steroidal anti-inflammatory drugs for the management of fever and pain in pediatric patients: a cross-sectional, multicenter study in Latin America, Africa, and the Middle East

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL

Pragmatic and Observational Research Pub Date : 2019-08-15 DOI:10.2147/POR.S168140

María Carolina Kamel Escalante, A. Abbas, A. Farah, Ernesto Rivera-Richardson, F. Burgos, Ilenia Forero, M. Murrieta-Aguttes, Mohamed El Laboudy, Ndeye Ramatoulaye Diagne-Gueye, Sergio B Barragán Padilla

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引用次数: 5

Abstract

Objective To evaluate the daily practice of pediatricians, physician-perceived reasons for unsatisfactory effects of treatment, and unmet needs in the management of acute pain and/or fever. Methods This was a multinational (n=13), multicenter, non interventional, cross-sectional study conducted in Latin America, Africa, and the Middle East in children under 16 years of age with fever (defined as a central body temperature ≥38°C) and/or acute pain (defined as pain lasting ≤6 weeks). Data were collected during a single visit using a structured physician-administered questionnaire and case report forms. Results A total of 2125 patients were recruited by 178 physicians between September 2010 and September 2011. From the 2117 analyzed patients, 1856 (87.7%) had fever, 705 (33.3%) had acute pain, and 446 (21.1%) had both. Of 1843 analyzed patients with fever, 1516 (82.3%) were previously prescribed a pharmacological treatment for the management of fever concomitantly with a non pharmacological approach, while 1817/1856 patients (97.9%) were currently receiving a prescribed pharmacological treatment for fever. Paracetamol/acetaminophen was the most commonly prescribed antipyretic medication during both previous (70.8%) and current (64.1%) consultations. With regard to acute pain management, 67.2% of the patients received previous and 93.9% received current treatment for pain. The most frequently prescribed analgesic during previous consultations was paracetamol/acetaminophen (53.7%), and the current most commonly prescribed analgesics were non steroidal anti-inflammatory drugs (55.2%). Treatment patterns for patients with both fever and acute pain were similar. Overall, 53.4% of the physicians reported poor treatment compliance as a reason for the unsatisfactory effect of the pain/fever treatment, and the most common unmet need was the availability of new drugs (according to 63.5% of the physicians). Conclusions Adequate management of fever was observed; however, due to the complex etiology of pediatric pain, better evaluation and management of pain in pediatrics is necessary.

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镇痛药、退烧药和非甾体抗炎药治疗儿科患者发烧和疼痛的处方模式：拉丁美洲、非洲和中东的一项横断面多中心研究

目的评估儿科医生的日常实践、医生对治疗效果不满意的原因以及对急性疼痛和/或发烧管理需求未得到满足的情况。方法这是一项在拉丁美洲、非洲和中东对16岁以下发烧（定义为中心体温≥38°C）和/或急性疼痛（定义为疼痛持续≤6周）儿童进行的跨国（n=13）、多中心、非介入性横断面研究。数据是在一次就诊期间使用结构化的医生管理的问卷和病例报告表收集的。结果2010年9月至2011年9月，178名医生共招募了2125名患者。在2117名分析患者中，1856人（87.7%）发烧，705人（33.3%）急性疼痛，446人（21.1%）两者兼有。在1843名分析的发烧患者中，1516名（82.3%）患者之前接受了药物治疗，同时采用非药物方法治疗发烧，而1817/1856名患者（97.9%）目前正在接受药物治疗。在以前（70.8%）和现在（64.1%）的会诊中，对乙酰氨基酚/对乙酰氨基苯酚是最常见的退烧药。在急性疼痛管理方面，67.2%的患者曾接受过疼痛治疗，93.9%的患者接受过目前的疼痛治疗。在之前的咨询中，最常用的止痛药是扑热息痛/对乙酰氨基酚（53.7%），目前最常用的镇痛药是非甾体抗炎药（55.2%）。发烧和急性疼痛患者的治疗模式相似。总的来说，53.4%的医生报告说，治疗依从性差是疼痛/发烧治疗效果不令人满意的原因，最常见的未满足需求是新药的可用性（63.5%的医生表示）。结论对发热进行了充分的管理；然而，由于儿童疼痛的病因复杂，有必要在儿科对疼痛进行更好的评估和管理。

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Pragmatic and Observational Research MEDICINE, GENERAL & INTERNAL-

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期刊介绍： Pragmatic and Observational Research is an international, peer-reviewed, open-access journal that publishes data from studies designed to closely reflect medical interventions in real-world clinical practice, providing insights beyond classical randomized controlled trials (RCTs). While RCTs maximize internal validity for cause-and-effect relationships, they often represent only specific patient groups. This journal aims to complement such studies by providing data that better mirrors real-world patients and the usage of medicines, thus informing guidelines and enhancing the applicability of research findings across diverse patient populations encountered in everyday clinical practice.