A simple and sensitive HPLC method for simultaneous quantification of macrocyclic spermidine alkaloids in root, stem and leaf of Tripterygium wilfordii

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-03-23 DOI:10.1556/1326.2022.01014

Liang Zhang, Weiwei Xu, Hongxia Jiang, Jianqun Liu

引用次数: 2

Abstract

There has been a lively interest on macrocyclic polyamine alkaloids due to their remarkable pharmacological activities such as anti-tumor, anti-inflammatory, anti-Alzheimer's disease and anti-parasitic. Tripterygium wilfordii is a widely used traditional Chinese medicine, which is abundant in alkaloids including macrocyclic polyamine alkaloids. However, there are rarely studies on macrocyclic spermidine alkaloids of T. wilfordii so far. In this article, we use three known macrocyclic spermidine alkaloids celafurine, celabenzine and celacinnine, and successfully develop a simple and sensitive HPLC method for simultaneous quantification of macrocyclic spermidine alkaloids in root, stem and leaf of T. wilfordii.

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高效液相色谱法同时测定雷公藤根、茎、叶中大环亚精胺生物碱的含量

由于大环多胺生物碱具有抗肿瘤、抗炎、抗阿尔茨海默病和抗寄生虫等显著的药理活性，人们对其产生了浓厚的兴趣。雷公藤是一种应用广泛的中药，含有丰富的生物碱，其中包括大环多胺生物碱。然而，到目前为止，对雷公藤大环亚精胺生物碱的研究还很少。本文采用三种已知的大环亚精胺生物碱——雷公藤、西拉本嗪和西拉辛，成功地建立了一种简单灵敏的高效液相色谱法同时测定雷公藤根、茎、叶中大环亚精胺生物碱的含量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.