Nanofibres in Drug Delivery Applications

IF 4 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Fibers Pub Date : 2023-02-17 DOI:10.3390/fib11020021

S. Farhaj, B. Conway, M. U. Ghori

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引用次数: 11

Abstract

Over the years, scientists have been continually striving to develop innovative solutions to design and fabricate medicines with improved therapeutic potential. Conventional dosage forms, such as tablets, capsules, and injections, are limited when exploited for advanced therapeutics, such as drug targeting. To cater to these limitations, nanofibres have emerged as novel nanomaterials to provide enhanced bioavailability, targeted drug release, extended drug release profile, minimum toxicity, and reduced dosage frequency, which has indisputably improved patient adherence and compliance. This review will concern understanding the potential of drug-loaded nanofibres in drug delivery while comprehending a detailed description of their different production methods. The literature has been thoroughly reviewed to appreciate their potential in developing nanofibrous-based pharmaceutical formulations. Overall, this review has highlighted the importance, versatility, and adaptability of nanofibres in developing medicines with varied drug release kinetics. Several problems must be resolved for their full commercial realisation, such as the drug loading, the initial burst effect, the residual organic solvent, the stability of active agents, and the combined usage of new or existing biocompatible polymers.

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纳米纤维在药物输送应用中的应用

多年来，科学家们一直在努力开发创新的解决方案，以设计和制造具有更高治疗潜力的药物。常规剂型，如片剂、胶囊和注射剂，在用于高级治疗（如药物靶向）时受到限制。为了满足这些限制，纳米纤维已成为新型纳米材料，可提供增强的生物利用度、靶向药物释放、延长药物释放谱、最小毒性和降低剂量频率，这无疑提高了患者的依从性和依从性。这篇综述将涉及了解载药纳米纤维在药物递送中的潜力，同时了解其不同生产方法的详细描述。已对文献进行了全面审查，以了解其在开发基于纳米纤维的药物制剂方面的潜力。总的来说，这篇综述强调了纳米纤维在开发具有不同药物释放动力学的药物中的重要性、多功能性和适应性。为了实现其完全商业化，必须解决几个问题，例如药物负载、初始爆裂效应、残留有机溶剂、活性剂的稳定性以及新的或现有的生物相容性聚合物的组合使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fibers Engineering-Civil and Structural Engineering

CiteScore

7.00

自引率

7.70%

发文量

审稿时长

11 weeks

期刊介绍： Fibers (ISSN 2079-6439) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications on the materials science and all other empirical and theoretical studies of fibers, providing a forum for integrating fiber research across many disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. The following topics are relevant and within the scope of this journal: -textile fibers -natural fibers and biological microfibrils -metallic fibers -optic fibers -carbon fibers -silicon carbide fibers -fiberglass -mineral fibers -cellulose fibers -polymer fibers -microfibers, nanofibers and nanotubes -new processing methods for fibers -chemistry of fiber materials -physical properties of fibers -exposure to and toxicology of fibers -biokinetics of fibers -the diversity of fiber origins