Computational and comparative investigation of hydrophobic profile of spike protein of SARS-CoV-2 and SARS-CoV

IF 1.8 4区生物学 Q3 BIOPHYSICS

Journal of Biological Physics Pub Date : 2022-11-23 DOI:10.1007/s10867-022-09615-x

Uma Shekhawat, Anindita Roy Chowdhury (Chakravarty)

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引用次数: 2

Abstract

The hydrophobic force is one of the most dominant factors in protein folding. A protein becomes functional only when it achieves its three-dimensional structure and stability upon folding. For a better understanding of the hydrophobic effects and their function in protein folding, quantitative measurement of the hydrophobicity of amino acid side chains is crucial. Spike protein is the primary structural protein in SARS-CoV-2 and SARS-CoV. This study explores how protein sequences in SARS-CoV-2 and SARS-CoV spike proteins encode hydrophobic interactions. Computational tools/techniques have been utilized to investigate the protein sequences of the spike proteins of SARS-CoV-2 and SARS-CoV. Investigations provided an estimate of hydrophobic distribution and its relative strength, indicating a hydrophobic pattern. Analysis of the spike protein's hydrophobic profile may help identify and treat the virus-caused disease; additionally, it can give an insight into the transmissibility and pathogenicity of the virus.

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SARS-CoV-2和SARS-CoV刺突蛋白疏水性谱的计算和比较研究

疏水力是蛋白质折叠中最主要的因素之一。只有当蛋白质在折叠时达到其三维结构和稳定性时，它才具有功能。为了更好地了解蛋白质折叠中的疏水效应及其功能，氨基酸侧链疏水性的定量测量至关重要。刺突蛋白是SARS-CoV-2和SARS-CoV的主要结构蛋白。本研究探讨了SARS-CoV-2和SARS-CoV刺突蛋白中的蛋白质序列如何编码疏水相互作用。利用计算工具/技术研究了SARS-CoV-2和SARS-CoV刺突蛋白的蛋白质序列。研究提供了疏水分布及其相对强度的估计，表明疏水模式。对刺突蛋白疏水性谱的分析可能有助于识别和治疗病毒引起的疾病;此外，它可以深入了解病毒的传播性和致病性。

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来源期刊

Journal of Biological Physics 生物-生物物理

CiteScore

3.00

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Many physicists are turning their attention to domains that were not traditionally part of physics and are applying the sophisticated tools of theoretical, computational and experimental physics to investigate biological processes, systems and materials. The Journal of Biological Physics provides a medium where this growing community of scientists can publish its results and discuss its aims and methods. It welcomes papers which use the tools of physics in an innovative way to study biological problems, as well as research aimed at providing a better understanding of the physical principles underlying biological processes.