Genetic association of rs7754840 and rs7756992 polymorphisms in the CDKAL1 gene and gestational diabetes mellitus in selected Filipino pregnant women

IF 0.5 Q4 REPRODUCTIVE BIOLOGY
M. Pineda-Cortel, Karlo Baybayan, Peter Bello, Latiffa Camenforte, S. Ching, Kathleen Conti, Jeremiah Ignacio, J. Diaz, Adrian Villavieja, J. Pandac, E. Alejandro
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引用次数: 2

Abstract

Objective: To investigate the possible association between rs7754840 and rs7756992 polymorphisms of CDKAL1 gene and susceptibility to gestational diabetes mellitus (GDM) in a Filipino pregnant population. Methods: A total of 101 patients with GDM and 99 women without GDM were included. Two CDKAL1 gene single nucleotide polymorphisms (SNPs), namely rs7754840 and rs7756992, were genotyped by using TaqMan allelic discrimination assays. Mann-Whitney U test, median and interquartile range were used to describe physical and biochemical characteristics. The differences in the genotype and allele distribution of the target genetic variants among the two groups of participants were assessed by using Chi-square test. Conformity to Hardy-Weinberg equilibrium was tested prior to conducting further analysis. Multiple logistic regression model was used to investigate the effects of the genotype models on GDM development. Results: There was no observed correlation between the genotypes of the rs7754840 SNP and oral glucose tolerance test parameters. Consequently, there was no significant association between genetic models of the rs7754840 SNP and GDM risk (additive OR 1.43, 95% CI 0.82-2.50, P=0.21; dominant OR 1.21, 95% CI 0.57-2.59, P=0.62; recessive OR 1.63, 95% CI 0.86-3.09, P=0.13). Conclusions: The results of this study suggest no association between CDKAL1 gene variant rs7754840 and GDM development in Filipino pregnant women. Further studies with a larger population should be performed to validate our findings.
CDKAL1基因rs7754840和rs7756992多态性与菲律宾孕妇妊娠期糖尿病的遗传相关性
目的:探讨CDKAL1基因rs7754840和rs7756992多态性与菲律宾妊娠人群妊娠期糖尿病(GDM)易感性的可能关系。方法:纳入101例GDM患者和99例非GDM妇女。用TaqMan等位基因鉴别法对两个CDKAL1基因单核苷酸多态性(SNPs)rs7754840和rs7756992进行了基因分型。Mann-Whitney U检验、中位数和四分位间距用于描述物理和生化特征。通过卡方检验评估两组参与者中目标遗传变异的基因型和等位基因分布的差异。在进行进一步分析之前,测试是否符合Hardy-Weinberg平衡。采用多元逻辑回归模型研究基因型模型对GDM发育的影响。结果:rs7754840 SNP基因型和口服糖耐量试验参数之间无相关性。因此,rs7754840 SNP的遗传模型与GDM风险之间没有显著关联(加性OR 1.43,95%CI 0.82-2.50,P=0.21;显性OR 1.21,95%CI 0.57-2.59,P=0.62;隐性OR 1.63,95%CI 0.86-3.09,P=0.13)。应该对更多的人群进行进一步的研究来验证我们的发现。
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来源期刊
Asian Pacific Journal of Reproduction
Asian Pacific Journal of Reproduction Veterinary-Veterinary (all)
CiteScore
1.70
自引率
0.00%
发文量
588
审稿时长
9 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.
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