Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin

IF 2 4区工程技术 Q3 ENGINEERING, CHEMICAL

Advances in Polymer Technology Pub Date : 2023-08-30 DOI:10.1155/2023/9452164

Hananeh Hamedfar, Tayebeh Zivari-Ghader, A. Akbarzadeh, S. Davaran

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Abstract

In addition to being a lipid-lowering medication, atorvastatin (ATV) is an anti-inflammatory agent. When there is a bone defect or inflammation of adjacent tissues, it aids in bone repair. This study aimed to develop a chitosan–alginate (CS/ALG)–tripolyphosphate (TPP)–ATV hybrid hydrogel as a drug delivery system, using a tissue engineering scaffold for the first time. For this purpose, a CS/ALG hydrogel crosslinked with TPP was developed. The delivery profile of ATV and its physicochemical properties such as particle size and hydrogel swelling percentage were determined. The structure and morphology of the hydrogels were analyzed using Fourier transform infrared spectroscopy and scanning electron microscopy. As a result, an alginate–chitosan hydrogel with a TPP crosslinker was prepared. The results revealed that drug loading was nearly complete, and the first hour revealed a 25% explosive release. The drug was gradually released over 10 hr at approximately 35%. The amount of crosslinker used significantly influenced the encapsulation gain and release profiles. Owing to its high porosity and swelling, the CS/ALG hydrogel crosslinked with PPT is an ideal scaffold for loading drugs, macromolecules, and cells.

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含阿托伐他汀壳聚糖-海藻酸盐支架的理化特性研究

阿托伐他汀（ATV）除了是一种降脂药物外，还是一种抗炎药。当出现骨缺损或相邻组织炎症时，它有助于骨修复。本研究旨在首次使用组织工程支架开发壳聚糖-海藻酸盐（CS/ALG）-三聚磷酸酯（TPP）-ATV混合水凝胶作为药物递送系统。为此，开发了一种与TPP交联的CS/ALG水凝胶。测定了ATV的递送特性及其物理化学性质，如粒径和水凝胶溶胀率。利用傅立叶变换红外光谱和扫描电子显微镜分析了水凝胶的结构和形态。结果，制备了具有TPP交联剂的藻酸盐-壳聚糖水凝胶。结果显示，药物装载几乎完成，第一个小时就有25%的爆炸性释放。药物在10年后逐渐释放 hr，约35%。所用交联剂的量显著影响包封增益和释放曲线。由于其高孔隙率和高溶胀性，与PPT交联的CS/ALG水凝胶是装载药物、大分子和细胞的理想支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Polymer Technology 工程技术-高分子科学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

9 months

期刊介绍： Advances in Polymer Technology publishes articles reporting important developments in polymeric materials, their manufacture and processing, and polymer product design, as well as those considering the economic and environmental impacts of polymer technology. The journal primarily caters to researchers, technologists, engineers, consultants, and production personnel.