Kinases: The "Indispensables"of the DNA Damage Response Cascade

V. Menon, M. M. Dcona
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Abstract

The human genome is exposed to a gamut of cellular and exogenous insults on a daily basis which needs to be monitored for proper cellular functioning and survival. This surveillance is undertaken by a myriad of protein players that ensure temporal and spatial regulation of cellular homeostasis. Kinases lie at the epicenter of the DNA damage response and exhibit a dynamic functionality, from responding to the damage to regulating the role of other proteins involved in detecting and repairing the damage. Here, we review some of the key kinases involved in DNA damage response pathways and their inhibitors that are either in clinical trials or have received approval for disease treatment.
激酶:DNA损伤反应级联的“不可或缺”
人类基因组每天都暴露在各种细胞和外源性损伤中,需要对其进行适当的细胞功能和存活监测。这种监测是由无数的蛋白质参与者进行的,以确保细胞稳态的时间和空间调节。激酶位于DNA损伤反应的中心,并表现出动态功能,从对损伤的反应到调节参与检测和修复损伤的其他蛋白质的作用。在这里,我们回顾了一些参与DNA损伤反应途径的关键激酶及其抑制剂,这些激酶要么正在临床试验中,要么已被批准用于疾病治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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