The FTO Gene rs9939609 Polymorphism and its Association with BAI as Well as Other Adiposity Markers

Archives of epidemiology Pub Date : 2018-12-24 DOI:10.29011/2577-2252.000026

U. Gupta, Kshetrimayum Surmala Devi, Meenal Dhall, R. Tyagi, S. Kapoor

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Abstract

The FTO Gene rs9939609 Polymorphism and its Association with BAI as Well as Other Adiposity Markers. Abstract Introduction: The Fat mass and obesity associated (FTO) rs9939609 gene polymorphism has been studied in many parts of the world to find its implication on obesity and Type 2 diabetes mellitus. Objective: The present study is conducted to find out the association of FTO gene polymorphism with adiposity markers among the adult population of North Delhi. Materials and Method: Anthropometric measurements and intravenous blood sample were collected from 247 individuals who were residing in Delhi for more than 15 years. Informed written consent was also taken before conducting the study from each individual. DNA (Deoxyribose Nucleic Acid) isolation and genotyping were carried out using standard protocol. Statistical analysis was done using SPSS version 17.0. Results: Maximum mean of waist circumference, body mass index and conicity index are found to be associated with the risk genotype of FTO marker. Conclusion: This study revealed the difference in the prediction of FTO genotypes on different adiposity markers.

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FTO基因rs9939609多态性及其与BAI及其他肥胖标志物的关联

FTO基因rs9939609多态性及其与BAI及其他肥胖标志物的关联摘要简介:脂肪质量与肥胖相关(Fat mass and obesity associated, FTO) rs9939609基因多态性在世界许多地区被研究，以发现其与肥胖和2型糖尿病的关系。目的:研究北德里成年人群中FTO基因多态性与肥胖标志物的关系。材料与方法:采集居住在德里15年以上的247人的人体测量数据和静脉血液样本。在进行研究之前，还获得了每个人的知情书面同意。DNA(脱氧核糖核酸)分离和基因分型采用标准方案。采用SPSS 17.0版本进行统计分析。结果:发现腰围、体重指数和圆度指数的最大平均值与FTO标记的危险基因型相关。结论:本研究揭示了FTO基因型在不同肥胖标记上的预测差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of epidemiology

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