Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior: antipsychotic effect of silkworm pupae

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Gehan S Georgy, Amany M Gad, H. Anwar, R. Taha, Aliaa A. M. Hassan
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Abstract

Background The pupae of mulberry silkworms, family Bombycidae, possess a great number of proteins that cover all of the necessary amino acids obligatory for well-being. Objective In this study, we aimed to evaluate the probable antipsychotic effect of pupae of mulberry silkworms in a rat model of schizophrenia prompted by ketamine on the cerebral cortex, hippocampus, and striatum, the brain areas involved in neuropsychiatric complaints. Materials and methods To this end, male albino rats were classified as follows: group 1 was the control group; group 2 animals were administered 135 mg/kg, p.o. silkworm pupae for 3 weeks; group 3 animals received vehicle for 3 weeks, and ketamine (30 mg/kg, i.p.) for the last 5 consecutive days of the experiment; and group 4 was the silkworm pupae and ketamine-treated group. Results The results revealed that treatment with silkworm pupae improved the exploration of schizophrenic rats in the novel object test and almost normalized their locomotor activity in the open field test. Additionally, silkworm pupae modulated the content of catecholamines and oxidative state in the cerebral cortex, hippocampus, and striatum of schizophrenic rats; however, the acetylcholine esterase activity was restored in the hippocampus only. Histopathological damages caused by ketamine are partially reduced by silkworm pupae. Conclusion Our data suggest that silkworm pupae, via neurobehavioral modulatory pathway, exhibit beneficial effects against psychomimetic influence of ketamine.
氯胺酮通过调节神经递质和行为诱导大鼠精神分裂症样状态:蚕蛹的抗精神病作用
背景家蚕科桑蚕的蛹含有大量的蛋白质,这些蛋白质覆盖了健康所必需的所有氨基酸。目的在本研究中,我们旨在评估桑蚕蛹在氯胺酮诱导的精神分裂症大鼠模型中对大脑皮层、海马体和纹状体的抗精神病作用。材料与方法将雄性白化大鼠分为:第一组为对照组;第2组给药135只 mg/kg,p.o.蚕蛹3周;第3组动物接受载体治疗3周,并接受氯胺酮(30 mg/kg,腹膜内注射);第4组为蚕蛹和氯胺酮治疗组。结果蚕蛹处理能提高精神分裂症大鼠在新对象试验中的探索能力,并能使其在野外试验中的运动活动几乎正常化。此外,蚕蛹还调节了精神分裂症大鼠大脑皮层、海马和纹状体的儿茶酚胺含量和氧化状态;然而,乙酰胆碱酯酶活性仅在海马中恢复。蚕蛹可部分减少氯胺酮引起的组织病理学损伤。结论蚕蛹通过神经行为调节途径,对氯胺酮的心理模拟作用有一定的抑制作用。
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来源期刊
Egyptian Pharmaceutical Journal
Egyptian Pharmaceutical Journal PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
0.00%
发文量
37
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