Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review

Korean Journal of Pediatrics Pub Date : 2019-10-02 DOI:10.3345/kjp.2019.00668

E. Jenabi, Sara Ataei, S. Bashirian

引用次数: 9

Abstract

A structured review study of drug interventions on sleep disorders in patients with autism spectrum disorders (ASD) has not been published to date. This systematic review aimed to investigate drug interventions for the treatment of sleep disorders in children with ASD. The Web of Science, PubMed, and Scopus databases were searched until March 2019. Study quality was assessed using the Delphi checklist. Due to the heterogeneity of the findings, a meta-analysis was not possible. Drug interventions for the treatment of sleep disorders in patients with ASD included melatonin, atomoxetine, and risperidone. Atomoxetine had no effect on sleep disorders in patients with ASD. A total of 10 studies were reviewed. Melatonin appears to be useful for the treatment of sleep problems in patients with ASD, but further studies are needed to determine the effects of other drugs.

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药物干预治疗自闭症谱系障碍儿童睡眠障碍的评价：一项系统综述

迄今为止，一项关于自闭症谱系障碍（ASD）患者睡眠障碍药物干预的结构化综述研究尚未发表。本系统综述旨在研究ASD儿童睡眠障碍的药物干预。搜索Web of Science、PubMed和Scopus数据库直到2019年3月。使用德尔菲检查表评估研究质量。由于研究结果的异质性，不可能进行荟萃分析。治疗ASD患者睡眠障碍的药物干预包括褪黑素、阿托莫西汀和利培酮。阿托莫西汀对ASD患者的睡眠障碍没有影响。共回顾了10项研究。褪黑素似乎有助于治疗ASD患者的睡眠问题，但还需要进一步的研究来确定其他药物的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Pediatrics

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.