Retro-reflective materials are important for safety purposes, such as enhancing the visibility of pedestrians at night when they wear garments with reflective materials and therefore reducing pedestrian fatalities. This has challenged different manufacturers to produce effective materials that provide the best retro-reflection. Most of these materials are applied as stripes on clothing, but can also extend to artisans using reflective yarns in their creations. Nevertheless, there is a lack of research and the synthesis of reflective yarns and African design patterns (due to its symbolic value for the African people) to create effective textiles that have the necessary properties for visibility at night. In this research work, a new approach is adopted by using a design process that combines jacquard weaving technology, reflective threads and African design patterns to produce retro-reflective textiles. The subsequent reflective effects captured in a darkroom show the retro-reflective ability of the samples. The testing carried out by using the Kawabata Evaluation System for Fabrics shows that the total hand value (THV) of the samples makes them suitable for men’s winter dress shirts and women’s thin winter dresses (with positive values) but not suitable for the summer garment (with negative values) counterparts respectively. This new approach might extend the ideation to produce retro-reflective textiles that can be applied for many different uses.