Restoration of olfactory dysfunctions by nanomaterials and stem cells-based therapies: Current status and future perspectives

IF 6.7 1区工程技术 Q1 CELL & TISSUE ENGINEERING

Journal of Tissue Engineering Pub Date : 2022-03-01 DOI:10.1177/20417314221083414

S. Yoo, Hae-Won Kim, Jun Hee Lee

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引用次数: 4

Abstract

Dysfunction in the olfactory system of a person can have adverse effects on their health and quality of life. It can even increase mortality among individuals. Olfactory dysfunction is related to many factors, including post-viral upper respiratory infection, head trauma, and neurodegenerative disorders. Although some clinical therapies such as steroids and olfactory training are already available, their effectiveness is limited and controversial. Recent research in the field of therapeutic nanoparticles and stem cells has shown the regeneration of dysfunctional olfactory systems. Thus, we are motivated to highlight these regenerative approaches. For this, we first introduce the anatomical characteristics of the olfactory pathway, then detail various pathological factors related to olfactory dysfunctions and current treatments, and then finally discuss the recent regenerative endeavors, with particular focus on nanoparticle-based drug delivery systems and stem cells. This review offers insights into the development of future therapeutic approaches to restore and regenerate dysfunctional olfactory systems.

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利用纳米材料和干细胞治疗嗅觉功能障碍:现状和未来展望

一个人的嗅觉系统功能障碍会对他们的健康和生活质量产生不利影响。它甚至会增加个体的死亡率。嗅觉功能障碍与许多因素有关，包括病毒后上呼吸道感染、头部创伤和神经退行性疾病。虽然一些临床疗法，如类固醇和嗅觉训练已经可用，但它们的有效性是有限的和有争议的。最近在治疗性纳米粒子和干细胞领域的研究表明，功能失调的嗅觉系统可以再生。因此，我们有动力强调这些再生方法。为此，我们首先介绍嗅觉通路的解剖学特征，然后详细介绍与嗅觉功能障碍相关的各种病理因素和目前的治疗方法，最后讨论最近的再生努力，特别关注基于纳米颗粒的药物输送系统和干细胞。这篇综述为恢复和再生功能失调的嗅觉系统的未来治疗方法的发展提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Tissue Engineering Engineering-Biomedical Engineering

CiteScore

11.60

自引率

4.90%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.