Pattern and Risk Factors of Liver Injury among Hospitalized Covid-19 Patients: The Experience of a Greek Referral Hospital

Abstract

Background: Although the new coronavirus (SARS-COV-2) affects predominantly the respiratory system, concomitant liver manifestations are common among COVID-19 patients. Aim: To investigate the prevalence and pattern of liver impairment (hepatocellular, cholestatic, mixed) and identify risk factors potentially associated with the liver injury in hospitalized patients with Covid-19. Materials and Methods: This retrospective study enrolled consecutive patients with Covid-19 who had evidence of liver injury on admission and/or during hospitalization in a tertiary hospital. Patient demographic, clinical and laboratory data were captured from the hospital's electronic data monitoring system. Univariate and multivariate logistic regression analysis were applied to identify risk factors for liver injury.