Synthesis and fungicidal activity of novel imidazo[4, 5-b]pyridine derivatives

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0003

Daoxin Wu, Minhua Liu, Zhong Li, Mingming Dang, Xingping Liu, Jianming Li, Lu Huang, Yeguo Ren, Zai Zhang, Weidong Liu, Aiping Liu

引用次数: 6

Abstract

Abstract A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

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新型咪唑并[4,5-b]吡啶衍生物的合成及其杀菌活性

摘要合成了一系列新的咪唑并[4,5-b]吡啶衍生物，并用核磁共振、质谱和元素分析对其结构进行了表征。生物测定结果表明，一些化合物对多孢Puccinia polysora具有良好的杀菌活性。特别是化合物7b的EC50值为4.00mg/L，与戊唑醇相当。并初步探讨了其构效关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.