Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Huimin Lian , Huimin Jiang , Lina Yi , Jing Sun , Huaping Xie , Ming Qiu , Limei Sun , Huifang Lin , Mingda Yang , Lin Qu , Haiyi Yang , Jing Lu , Hanri Zeng
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引用次数: 0

Abstract

Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied. In this study, we analyzed the incidence of EV-A71 infection and seroepidemiology in Guangzhou City, China. From 2019 to 2021, 167,920 clinically confirmed HFMD cases were reported in Guangzhou. In 6,868 enterovirus-positive samples, Coxsackievirus A6 and Coxsackievirus A16 were dominant genotypes, and only 3 EV-A71-positive samples were detected, highlighting the deficient epidemic activity of EV-A71. Microneutralization assay was performed on 1,000 representative serum samples. Notably, the seroprevalence and geometric mean titer (GMT) decreased significantly in 2020, and that in the < 3-year age group were increased and even higher than that in 3–5-year age group in 2019 and 2021, which was contrary to our previous surveillance result and other studies in Guangzhou. Furthermore, a moderate decline of GMT level was observed following the vaccination, but the seropositive serums were still detected for 49 months after second immunization, suggesting the long-term persistence of the immunity. Our seroepidemiology study revealed relatively higher neutralizing antibody activity in the susceptible population after the EV-A71 vaccine was adopted in 2016 in Guangzhou. It may be one of the reasons for the lower epidemic activity of EV-A71 in Guangzhou from 2019 to 2021.

2019-2021年广州地区人肠道病毒A71血清阳性率分析
肠病毒A71 (EV-A71)是一种重要的手足口病病原。EV-A71灭活疫苗于2016年在中国获得批准。然而,疫苗接种后EV-A71的血清阳性率及其与人群中EV-A71流行的潜在关联的研究很少。在本研究中,我们分析了中国广州市EV-A71感染的发病率和血清流行病学。2019 - 2021年,广州市累计报告手足口病临床确诊病例167920例。在6868份肠病毒阳性样本中,柯萨奇病毒A6和柯萨奇病毒A16为优势基因型,EV-A71阳性样本仅检测到3份,说明EV-A71的流行活性不足。对1000份有代表性的血清样品进行微量中和试验。值得注意的是,血清阳性率和几何平均滴度(GMT)在2020年显著下降;2019年和2021年3岁年龄组有所增加,甚至高于3- 5岁年龄组,这与我们之前在广州的监测结果和其他研究结果相反。此外,在接种疫苗后,观察到GMT水平中度下降,但在第二次免疫后49个月仍检测到血清阳性血清,表明免疫的长期持久性。我们的血清流行病学研究显示,2016年广州地区接种EV-A71疫苗后,易感人群中和抗体活性相对较高。这可能是2019 - 2021年广州EV-A71疫情活动较低的原因之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
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