Lifestyle and Circadian Health: Where the Challenges Lie?

IF 2.3 Q3 NUTRITION & DIETETICS

Nutrition and Metabolic Insights Pub Date : 2019-08-01 DOI:10.1177/1178638819869024

N. J. Gupta

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引用次数: 14

Abstract

Modern life is facilitated by extended light hours at night and longer hours of eating. Compromised sleep, sedentary life, and modern diet adversely affect human health. Studies emphasizing importance of evidence-driven longitudinal studies on daily rhythms of human eating and sleeping behaviour provide a baseline for adequate insight into causal factors for circadian misalignment. Molecular chronobiology studies in animal models debrief endogenous regulation of organismal circadian clock; their regulation by environmental cues and how they segregate incompatible processes. But effective utilization of the knowledge needs randomized chrono-therapeutic intervention trials in humans. However, nutrition, activity, and lifestyle being society specific, baseline longitudinal studies must precede intervention trials as primary method to decipher circadian disruption. Our pilot survey studies investigating current lifestyle trends responsible for circadian rhythm disruption revealed that accelerated urban life, more than 8 hours work operations and long commutes to work inflict a sleep loss in Indian working women living in metropolitan cities. This sleep loss is sufficient to adversely impact their wellness. Besides, daily work routines and fast-food popularity have contributed to circadian disruption in daily rhythms of eating and sleep, enhancing disease consequences.

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生活方式和生理健康:挑战在哪里?

延长夜间光照时间和延长进食时间有利于现代生活。睡眠不足、久坐不动和现代饮食会对人类健康产生不利影响。强调证据驱动的人类日常饮食和睡眠行为节奏纵向研究重要性的研究为充分了解昼夜节律失调的因果因素提供了基线。动物模型中的分子时间生物学研究报告了生物体生物钟的内源性调节；它们通过环境线索的调节，以及它们如何分离不相容的过程。但有效利用这些知识需要在人类中进行随机时间治疗干预试验。然而，营养、活动和生活方式是特定于社会的，基线纵向研究必须先于干预试验，作为解读昼夜节律紊乱的主要方法。我们调查了导致昼夜节律紊乱的当前生活方式趋势的试点调查研究表明，城市生活的加速、超过8小时的工作时间和长时间的通勤会导致生活在大都市的印度职业女性睡眠不足。这种睡眠不足足以对他们的健康产生不利影响。此外，日常工作和快餐的流行导致了日常饮食和睡眠节奏的昼夜节律紊乱，加剧了疾病的后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.

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