Immunotoxicity of mercury: Pathological and toxicological effects

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2017-01-02 DOI:10.1080/10590501.2016.1278299

Faheem Maqbool, K. Niaz, F. Hassan, Fazlullah Khan, M. Abdollahi

引用次数: 44

Abstract

ABSTRACT Mercury (Hg) is toxic and hazardous metal that causes natural disasters in the earth's crust. Exposure to Hg occurs via various routes; like oral (fish), inhalation, dental amalgams, and skin from cosmetics. In this review, we have discussed the sources of Hg and its potential for causing toxicity in humans. In addition, we also review its bio-chemical cycling in the environment; its systemic, immunotoxic, genotoxic/carcinogenic, and teratogenic health effects; and the dietary influences; as well as the important considerations in risk assessment and management of Hg poisoning have been discussed in detail. Many harmful outcomes have been reported, which will provide more awareness.

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汞的免疫毒性:病理和毒理学效应

汞是一种有毒有害的金属，会在地壳中引发自然灾害。接触汞的途径多种多样；如口服（鱼）、吸入、牙科汞合金和化妆品皮肤。在这篇综述中，我们讨论了汞的来源及其对人类造成毒性的可能性。此外，我们还回顾了其在环境中的生化循环；其系统性、免疫毒性、遗传毒性/致癌和致畸健康影响；以及饮食影响；以及汞中毒风险评估和管理中的重要考虑因素。已经报告了许多有害的结果，这将提高人们的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.