The relationship of peripheral blood single uncoding RNA-25-3p expression level and the sertraline efficacy in patients with panic disorder

中华行为医学与脑科学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1674-6554.2019.11.007

Wenjiao Min, Chenghui Yang, Shuya Pan, Yaoying Zhang, Ying He

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引用次数: 0

Abstract

Objective To identify potential relationship between single uncoding RNA-25-3p (miR-25-3p) expression level and the sertraline efficacy in patients with panic disorder. Methods Sixty cases of patients with panic disorder(case group) and sixty healthy-controls(control group) were collected with demographic data and peripheral venous blood before and after treatment.All the patients were evaluated using the 14-item Hamilton Anxiety Rating Scale (HAMA) and Panic Disorder Severity Scale (PDSS) at baseline, and then received sertraline treatment for 6 weeks.After six-week treatment, each patient was evaluated again with HAMA and PDSS.RT-PCR was used to detect the level of miR-25-3p expression. Results There was no significant difference in the miR-25-3p levels between control group (1.27±0.32) and case group (1.73±1.09) before treatment(t=1.53, P=0.14), but the levels in case group were much higher than that in control group after the treatment (5.72±4.13 vs 1.73±1.09, t=-2.15, P=0.04). Besides, the changes of the miR-25-3p levels were positively related with both the changes of PDSS3 and PDSS7 items before and after the treatment (r=0.60, P=0.02 for PDSS3 and r=0.61, P=0.02 for PDSS7). Conclusions miR-25-3p is associated with the drug efficacy and the outcome of some clinical symptoms of panic disorder.These findings might provide some evidence for the individualized treatment of patients with panic disorder according to regulation of gene expression in the future. Key words: Panic disorder; miR-25-3p; Sertraline; Effect

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惊恐障碍患者外周血单个未编码RNA-25-3p表达水平与舍曲林疗效的关系

目的探讨惊恐障碍患者单非编码RNA-25-3p (miR-25-3p)表达水平与舍曲林疗效的潜在关系。方法收集60例惊恐障碍患者(病例组)和60例健康对照(对照组)治疗前后的人口学资料和外周静脉血。基线采用14项汉密尔顿焦虑评定量表(HAMA)和惊恐障碍严重程度量表(PDSS)进行评估，然后给予舍曲林治疗6周。治疗6周后，再次用HAMA和PDSS对每位患者进行评估。RT-PCR检测miR-25-3p的表达水平。结果治疗前对照组miR-25-3p水平(1.27±0.32)与治疗前病例组miR-25-3p水平(1.73±1.09)比较差异无统计学意义(t=1.53, P=0.14)，治疗后病例组miR-25-3p水平明显高于治疗前对照组(5.72±4.13 vs 1.73±1.09,t=-2.15, P=0.04)。此外，治疗前后miR-25-3p水平的变化与PDSS3、PDSS7项目的变化均呈正相关(PDSS3 r=0.60, P=0.02; PDSS7 r=0.61, P=0.02)。结论miR-25-3p与惊恐障碍的药物疗效及部分临床症状的预后有关。这些发现可能为今后根据基因表达调控对惊恐障碍患者进行个体化治疗提供一些依据。关键词:恐慌症;miR-25-3p;舍曲林;效果

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来源期刊

中华行为医学与脑科学杂志

自引率

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发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.