The effect of serum proteins on apatite growth for 45S5 Bioglass and common sol-gel derived glass in SBF

Q1 Materials Science

Biomedical Glasses Pub Date : 2018-02-02 DOI:10.1515/bglass-2018-0002

Sen Lin, Julian R. Jones

引用次数: 8

Abstract

Abstract The inhibitive effects of serum proteins on apatite growth was compared between melt-derived 45S5 Bioglass® and sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO). By using techniques of XRD, TEM and Raman spectroscopy, the transformation of amorphous calcium phosphate to crystalline apatite, and the resulting size and aspect ratio of the crystals, in simulated body fluid (SBF), was seen to decrease in the presence of serum. XRD showed more rapid HA formation on Bioglass particles, compared to that forming on 70S30C particles, however TEM showed similar size and frequency of the needle-like crystals. Phosphate reduction in SBF was similar for Bioglass and 70S30C. Calcium carbonate formation was more likely on the phosphate-free sol-gel glass than on Bioglass.

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血清蛋白对45S5生物玻璃和普通溶胶-凝胶衍生玻璃磷灰石生长的影响

摘要比较了45S5生物玻璃®和70S30C (70 mol% SiO2, 30 mol% CaO)的溶胶-凝胶生物活性玻璃对磷灰石生长的抑制作用。通过XRD、TEM和拉曼光谱分析，在模拟体液(SBF)中观察到无定形磷酸钙向结晶磷灰石的转变，以及由此产生的晶体尺寸和纵横比在血清的存在下减小。XRD显示，与70S30C颗粒相比，生物玻璃颗粒上HA的形成速度更快，但TEM显示针状晶体的大小和频率相似。生物玻璃和70S30C在SBF中的磷酸盐还原相似。与生物玻璃相比，无磷酸盐溶胶-凝胶玻璃更容易形成碳酸钙。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.