The impact of diabetes on sarcopenia in community-dwelling older adults in India: key findings from the longitudinal ageing study in India (LASI)

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-01 DOI:10.1016/j.deman.2023.100158

Sayani Das

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引用次数: 0

Abstract

Background

Diabetes has become a major public health issue in India, and understanding its impact on skeletal muscle health is crucial for addressing the elevated risk of sarcopenia among individuals with diabetes. While the association between diabetes and sarcopenia has been extensively studied worldwide, there is a notable lack of research focusing on this relationship within the Indian community-dwelling geriatric population. Therefore, this study aimed to explore the influence of diabetes on sarcopenia among older adults living in community settings in India.

Methodology

The study used data from the Longitudinal Aging Study in India (LASI), Wave 1 (2017–18). It was focused on older adults aged 60 years and above living in community settings in India, including both males and females. This study followed the Asian Working Group on Sarcopenia (2019) guidelines, utilizing a screening tool that assessed sarcopenia through muscle (handgrip) strength, physical performance, and appendicular skeletal muscle mass (ASM). The presence of diabetes was determined through a self-reported approach, where participants disclosed their diabetes diagnosis as provided by healthcare professionals. To examine the association between diabetes and sarcopenia, the study utilized logistic regression analysis to calculate the adjusted odds ratio (AOR) and corresponding 95% confidence interval (CI).

Results

Present study included 27,241 individuals, with sarcopenia prevalent in 27.0% of participants. 3.4% had both sarcopenia and diabetes, 23.5% had sarcopenia only, 11.7% had diabetes only, and 61.3% had neither. After adjusting for confounding variables, participants with diabetes had a significantly higher odds ratio of 1.14 (95% CI 1.06–1.26, p < 0.001) for sarcopenia.

Conclusions

The study established that diabetes is a risk factor for sarcopenia in older adults living in India. Early identification and management are essential to mitigate sarcopenia, emphasizing the importance of addressing both conditions in healthcare.

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糖尿病对印度社区老年人少肌症的影响：印度纵向老龄化研究的关键发现

糖尿病已成为印度的一个主要公共卫生问题，了解其对骨骼肌健康的影响对于解决糖尿病患者肌肉减少症风险升高的问题至关重要。虽然糖尿病和肌肉减少症之间的关系在世界范围内得到了广泛的研究，但在印度社区居住的老年人口中，这种关系的研究明显缺乏。因此，本研究旨在探讨糖尿病对印度社区老年人肌肉减少症的影响。该研究使用了印度纵向老龄化研究(LASI)第1期(2017-18)的数据。研究的重点是生活在印度社区环境中的60岁及以上老年人，包括男性和女性。本研究遵循亚洲肌肉减少症工作组(2019)指南，利用一种筛选工具，通过肌肉(握力)力量、身体表现和阑尾骨骼肌质量(ASM)来评估肌肉减少症。糖尿病的存在是通过自我报告的方法确定的，参与者披露了由医疗保健专业人员提供的糖尿病诊断。为了检验糖尿病与肌肉减少症之间的关系，本研究采用logistic回归分析计算校正优势比(AOR)和相应的95%置信区间(CI)。结果本研究纳入27,241人，27.0%的参与者患有肌肉减少症。3.4%同时患有肌肉减少症和糖尿病，23.5%仅患有肌肉减少症，11.7%仅患有糖尿病，61.3%两者都没有。在调整了混杂变量后，糖尿病患者的优势比为1.14 (95% CI 1.06-1.26, p <0.001)。该研究确定糖尿病是印度老年人肌肉减少症的一个危险因素。早期识别和管理对于减轻肌肉减少症至关重要，强调在医疗保健中解决这两种情况的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.