Nutrition in sickle cell disease: recent insights

IF 1.3 Q4 NUTRITION & DIETETICS

Nutrition and Dietary Supplements Pub Date : 2019-05-23 DOI:10.2147/NDS.S168257

K. Umeakunne, J. Hibbert

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引用次数: 8

Abstract

Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/reuY48oNE-w Abstract: A cure for sickle cell anemia (SCA) is not available to all who have inherited this devastating genetically inherited disease. However, increasing knowledge that nutritional problems are fundamental to the severity of the disease, has produced interest in promoting dietary supplementation for treating these patients. This review seeks to emphasize the understanding that both children and adults with sickle cell disease require much higher energy and protein consumption (more macronutrient intake) than healthy individuals and tend to suffer from undernutrition if energy intake is consistently low. Shortages may also exist for micronutrients, eg, Glutathione, which has both anti-inflammatory and anti-oxidant properties. Both chronic inflammation and oxidant stress are central issues for increased sickle cell disease severity. In conclusion, dedicating more effort and resources to establishing recommended dietary reference intakes (DRIs)/recommended dietary allowances (RDAs) for SCA patients is essential, and nutritional intervention should be included as an adjunct treatment in tandem with standard practice.

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镰状细胞病的营养:最近的见解

把你的智能手机对准上面的代码。如果您有QR码阅读器，视频摘要将出现。摘要:镰状细胞性贫血(SCA)的治愈方法并非适用于所有患有这种毁灭性遗传疾病的人。然而，越来越多的人认识到，营养问题是疾病严重程度的基础，这引起了人们对促进膳食补充治疗这些患者的兴趣。本综述旨在强调这样一种认识，即患有镰状细胞病的儿童和成人都需要比健康人更高的能量和蛋白质消耗(更多的宏量营养素摄入)，如果能量摄入持续较低，则容易出现营养不良。微量营养素也可能短缺，例如具有抗炎和抗氧化特性的谷胱甘肽。慢性炎症和氧化应激都是镰状细胞病严重程度增加的核心问题。综上所述，投入更多的精力和资源来建立SCA患者的推荐膳食参考摄入量(DRIs)/推荐膳食摄入量(RDAs)是必不可少的，营养干预应作为一种辅助治疗与标准实践相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Dietary Supplements NUTRITION & DIETETICS-

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Nutrition and Dietary Supplements is an international, peer-reviewed, open access journal focusing on research into nutritional requirements in health and disease, impact on metabolism and the identification and optimal use of dietary strategies and supplements necessary for normal growth and development. Specific topics covered in the journal include: Epidemiology, prevalence of related disorders such as obesity, diabetes, dyslipidemias Biochemistry and cellular metabolism of nutrients Effect of nutrition on metabolic control Impact of hormones and genetics on nutrient handling Identification of cofactors and development of effective supplementation strategies Dietary strategies Behavior modification Consumer and patient adherence, quality of life Public Health Policy & Health Economics.