Correlation of Body Mass Index with Epidermal Biophysical Properties Varies with Gender in Chinese

IF 2.8 4区医学 Q2 DERMATOLOGY

Skin Pharmacology and Physiology Pub Date : 2022-04-04 DOI:10.1159/000524295

L. Ye, Q. Lai, S. Wen, Xiaohua Wang, Bin Yang, M. Man

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引用次数: 8

Abstract

Background: Epidermal function is associated with diabetes and renal disease. Whether obesity can reflect the changes in epidermal function is not clear yet. Objective: We assessed here the correlation of epidermal functions with body mass index (BMI) in a large Chinese cohort. Methods and Subjects: A total of 1,405 Chinese aged 21–98 years old were enrolled in this study. Epidermal functions, including transepidermal water loss (TEWL), stratum corneum hydration, and skin surface pH, were measured on the flexor forearm and the shin. Subjects’ height and body weight were also measured. Results: Age positively correlated with both TEWL and skin surface pH, while it negatively correlated with stratum corneum hydration on both the forearm and the shin of females. Similarly, age positively correlated with skin surface pH, while negatively correlating with stratum corneum hydration on both the forearm and the shin of males. In females, BMI positively correlated with skin surface pH, while it negatively correlated with stratum corneum hydration on both the forearm and the shin. However, BMI correlated neither with skin surface pH on both the forearm and the shin nor with stratum corneum hydration on the shin of males. Conclusion: These results demonstrate that correlations of BMI with age and epidermal functions vary with gender.

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中国人体重指数与表皮生物物理特性的相关性因性别而异

背景：表皮功能与糖尿病和肾脏疾病有关。肥胖是否能反映表皮功能的变化尚不清楚。目的：我们在一个大型中国队列中评估了表皮功能与体重指数（BMI）的相关性。方法和受试者：本研究共招募了1405名年龄在21-98岁之间的中国人。测量前臂屈肌和胫骨的表皮功能，包括经表皮失水（TEWL）、角质层水合作用和皮肤表面pH值。还测量了受试者的身高和体重。结果：女性的年龄与TEWL和皮肤表面pH呈正相关，而与前臂和胫骨的角质层水合作用呈负相关。同样，年龄与男性前臂和胫骨的皮肤表面pH呈正相关，而与角质层水合作用呈负相关。在女性中，BMI与皮肤表面pH呈正相关，而与前臂和胫骨的角质层水合作用呈负相关。然而，BMI既与前臂和胫骨的皮肤表面pH值无关，也与男性胫骨的角质层水合作用无关。结论：这些结果表明，BMI与年龄和表皮功能的相关性因性别而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.