Reliable cognitive change following unilateral deep brain stimulation in essential tremor.

IF 1.4 4区 心理学 Q4 CLINICAL NEUROLOGY
Applied Neuropsychology-Adult Pub Date : 2024-07-01 Epub Date: 2022-03-15 DOI:10.1080/23279095.2022.2048303
Stephanie Kielb, Claire Speelman, Laura Boxley, Darrin Aase, Erica Dawson, Barbara Changizi, Aristide Merola, Vibhor Krishna, Christopher Nguyen
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Abstract

Objective: This retrospective analysis assessed regression-based reliable change (RC) of cognition in a sample of essential tremor (ET) patients who underwent unilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM-DBS).Method: Thirty patients (mean age at pre-evaluation = 70.4 ± 6.3 years) underwent neuropsychological evaluation pre- and post-unilateral VIM-DBS placement (mean time between pre and post-evaluation = 13.1 ± 4.0 months). Paired samples t-tests and RC analyses were employed.Results: No significant within-group differences were observed when cognitive scores were compared between evaluations. The vast majority of patients demonstrated stability across pre-and post-surgical evaluations (i.e. 29 out of 30); however, those with high-risk co-morbid medical conditions may be vulnerable to post-surgical cognitive decline as indicated by RC measures.Conclusions: The use of regression-based RC indices to assess individual cognitive changes between pre and post-surgical evaluations control for systematic and measurement errors that can occur over repeated evaluations, and may be able to identify cognitive changes that evade detection in traditional within-group comparisons.

原发性震颤单侧深部脑刺激后可靠的认知变化。
目的:本回顾性分析评估了接受单侧丘脑腹侧中间核(VIM-DBS)脑深部刺激的原发性震颤(ET)患者样本的认知的基于回归的可靠变化(RC) ± 6.3 年)接受了单侧VIM-DBS植入前后的神经心理学评估(评估前后的平均时间=13.1 ± 4 月)。采用配对样本t检验和RC分析。结果:当比较评估之间的认知得分时,没有观察到显著的组内差异。绝大多数患者在术前和术后评估中表现出稳定性(即30例中有29例);然而,正如RC测量所表明的那样,那些患有高风险合并疾病的患者可能容易出现术后认知能力下降。结论:使用基于回归的RC指数来评估手术前和手术后评估之间的个体认知变化,可以控制重复评估中可能出现的系统性和测量性错误,并可能能够识别传统组内比较中无法检测到的认知变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
CiteScore
4.50
自引率
11.80%
发文量
134
期刊介绍: pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.
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