Comparison of Fasting Insulin Level, Homeostatic Model of Insulin Resistance, and Lipid Levels between Patients with Primary Hypertension and Normotensive Subjects

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL
Rithvik Ramesh, Viswanathan Pandurangan, Sudha Madhavan, D. Srinivasan, E. Bhaskar, Lakshmi Marappa, Aiswarya M Nair, Vaasanthi Rajendran, Priyadarshini Varadaraj
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Abstract

Background Hyperinsulinemia and insulin resistance occurs in obese patients with primary hypertension independent of diabetes and obesity. This study was aimed at assessing serum fasting insulin levels, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum lipid levels in non-obese patients with primary hypertension when compared to normotensive subjects. Methods This observational study comprised 100 patients over 18 years of age, divided into two groups. The hypertensive group comprised non-obese patients with primary hypertension (n=50); the normotensive group comprised normotensive age- and sex-matched individuals (n=50). Patients with diabetes, impaired fasting glucose, obesity, and other causative factors of insulin resistance were excluded from the study. Serum fasting insulin levels and fasting lipid profiles were measured, and insulin resistance was calculated using HOMA-IR. These data were compared between the two groups. Pearson’s correlation coefficient was used to assess the extent of a linear relationship between HOMA-IR and to evaluate the association between HOMA-IR and systolic and diastolic blood pressures. Results Mean serum fasting insulin levels (mIU/L), mean HOMA-IR values, and fasting triglyceride levels (mg/dL) were significantly higher in the hypertensive versus normotensive patients (10.32 versus 6.46, P<0.001; 1.35 versus 0.84, P<0.001; 113.70 versus 97.04, P=0.005, respectively). The HOMA-IR levels were associated with systolic blood pressure (r value 0.764, P=0.0005). Conclusion We observed significantly higher fasting insulin levels, serum triglyceride levels, and HOMA-IR reflecting hyperinsulinemia and possibly an insulin-resistant state among primary hypertension patients with no other causally linked factors for insulin resistance. We observed a significant correlation between systolic blood pressure and HOMA-IR.
原发性高血压患者与正常人空腹胰岛素水平、胰岛素抵抗稳态模型及脂质水平的比较
背景:高胰岛素血症和胰岛素抵抗发生在与糖尿病和肥胖无关的肥胖原发性高血压患者中。本研究旨在评估非肥胖原发性高血压患者与正常高血压患者的空腹胰岛素水平、胰岛素抵抗稳态模型评估(HOMA-IR)和血脂水平。方法观察性研究纳入100例18岁以上患者,随机分为两组。高血压组为非肥胖原发性高血压患者(n=50);正常血压组由年龄和性别匹配的正常血压个体组成(n=50)。伴有糖尿病、空腹血糖受损、肥胖和其他胰岛素抵抗因素的患者被排除在研究之外。测定空腹血清胰岛素水平和空腹血脂,并用HOMA-IR计算胰岛素抵抗。将这些数据在两组之间进行比较。Pearson相关系数用于评估HOMA-IR之间的线性关系程度,以及评估HOMA-IR与收缩压和舒张压之间的关系。结果高血压患者的平均空腹血清胰岛素水平(mIU/L)、平均HOMA-IR值和空腹甘油三酯水平(mg/dL)显著高于正常高血压患者(10.32比6.46,P<0.001;1.35 vs 0.84, P<0.001;113.70 vs 97.04, P=0.005)。HOMA-IR水平与收缩压相关(r值0.764,P=0.0005)。结论:我们观察到原发性高血压患者空腹胰岛素水平、血清甘油三酯水平和HOMA-IR水平明显升高,反映了高胰岛素血症和可能的胰岛素抵抗状态,没有其他与胰岛素抵抗相关的因果因素。我们观察到收缩压和HOMA-IR之间有显著的相关性。
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来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
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